Document Detail

Reduction in skin reactions to histamine after a hypnotic procedure.
MedLine Citation:
PMID:  8771624     Owner:  NLM     Status:  MEDLINE    
This study sought to test whether a cognitive-hypnotic intervention could be used to decrease skin reactivity to histamine and whether hypnotizability, physiological variables, attitudes, and mood would influence the size of the skin weals. Thirty eight subjects undertook three individual laboratory sessions; a pretest session to determine sensitivity to histamine, a control session, and an intervention session during which the subject experienced a cognitive-hypnotic procedure involving imagination and visualization. Compared with the control session, most subjects (32 of 38) decreased the size of their weals measured during the intervention session, and the differences between the weal sizes produced in the two sessions were highly significant (N = 38; t = 4.90; p < .0001). Mood and physiological variables but not hypnotizability scores proved to be effective in explaining the skin test variance and in predicting weal size change. Feelings of irritability and tension and higher blood pressure readings were associated with less change in weal size (i.e., a continuation of reactivity similar to that found in the control session without the cognitive-hypnotic intervention), and peacefulness and a lower blood pressure were associated with less skin reactivity during the intervention. This study has shown highly significant results in reducing skin sensitivity to histamine using a cognitive-hypnotic technique, which indicates some promise for extending this work into the clinical area.
T M Laidlaw; R J Booth; R G Large
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  58     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Department of Psychiatry and Behavioral Science, School of Medicine, University of Auckland, New Zealand.
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MeSH Terms
Analysis of Variance
Attitude to Health
Blood Pressure / physiology
Histamine / adverse effects*
Hypersensitivity / psychology*,  therapy
Imagery (Psychotherapy)
Internal-External Control
Intervention Studies
Irritable Mood / physiology
Middle Aged
Regression Analysis
Relaxation Therapy
Skin Test End-Point Titration / psychology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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