| Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism. | |
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MedLine Citation:
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PMID: 9369304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-aminobutyric acid (GABA)/substance P (SP) neurons and GABA/enkephalin (Enk) neurons in the striatum exert opposing influence on the regulation of movement. The loss of GABA/SP neurons results in hypokinetic disorders (parkinsonism), whereas the loss of GABA/Enk neurons results in hyperkinetic disorders (e.g. chorea). The present study determined age-related changes in the beta-preprotachykinin (the precursor of SP) and preproenkaphalin (the precursor of Enk) messenger RNA (mRNA) ratio in the postmortem human putamen using the reverse transcription-polymerase chain reaction (RT-PCR). The ratio of beta-preprotachykinin to preproenkephalin mRNA expression decreased with age. The reduction in the beta-preprotachykinin/preproenkephalin mRNA ratio was more marked in cases with multiple small infarcts (status lacunaris) in the putamen. These findings may in part explain the susceptibility of the elderly, particularly of those with ischemic changes in the striatum to hypokinetic disorders. |
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Authors:
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H Tohgi; K Utsugisawa; M Yoshimura; M Yamagata; Y Nagane; K Saitoh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 768 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-18 Completed Date: 1997-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 86-90 Citation Subset: IM |
Affiliation:
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Department of Neurology, Iwate Medical University, Morioka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / metabolism* Cerebral Infarction / metabolism* Disease Susceptibility Enkephalins / genetics* Female Humans Linear Models Male Middle Aged Parkinson Disease / metabolism Polymerase Chain Reaction / methods Protein Precursors / genetics* Putamen / metabolism* RNA, Messenger / biosynthesis* Tachykinins / genetics* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Enkephalins; 0/Protein Precursors; 0/RNA, Messenger; 0/Tachykinins; 0/preprotachykinin; 93443-35-7/preproenkephalin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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