Document Detail

Reduction in pulmonary blood volume during positive end-expiratory pressure.
MedLine Citation:
PMID:  6350709     Owner:  NLM     Status:  MEDLINE    
The response of intravascular (PBV) and extravascular (EVLW) pulmonary fluid volumes to varying degrees of positive end-expiratory pressure (PEEP) was examined using double indicator techniques (thermal green dye) in six open-chest anesthetized dogs during the production of oleic acid (0.15 cc/kg)-induced pulmonary injury. Data were obtained at a control state, then 1.5 hr after the oleic acid was injected. Positive-end expiratory pressure (5, 10, 15, and 20 cm H2O) consistently reduced cardiac output prior to and after oleic acid edema was created, with greater reductions occurring with higher levels of PEEP. Increasing amounts of PEEP consistently produced greater reductions in PBV (with and without pulmonary edema), though without significant effect on EVLW. PBV declined from 6.0 +/- 2.4 to 4.0 +/- 1.0 ml/kg with 20 cm H2O of PEEP (P less than .01) in the control state and 4.4 +/- 2.1 to 2.9 +/0 0.9 ml/kg (P less than .01) after oleic acid administration. It is concluded that PEEP significantly reduced intravascular pulmonary fluid volumes along with cardiac output, without changing EVLW. While the effects of altered left ventricular geometry were not examined, the displacement of blood from the central to the peripheral circulation during PEEP must substantially contribute to reductions in systemic flow.
R A Slutsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  35     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
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MeSH Terms
Blood Volume* / drug effects
Body Water / analysis,  drug effects,  physiology
Lung / blood supply,  physiology*
Oleic Acid
Oleic Acids / administration & dosage
Positive-Pressure Respiration*
Pulmonary Edema / physiopathology*
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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