| Reduction in p53 synthesis during differentiation of Friend-erythroleukemia cells. Correlation with the commitment to terminal cell division. | |
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MedLine Citation:
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PMID: 6354748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The process of cell differentiation in Friend-erythroleukemia cells was accompanied by 80-90% inhibition of p53 synthesis. This decrease was found to be linked to changes in cell-cycle distribution characteristics of the growth arrest program during differentiation rather than to the induction of the globin genes. The shut-off in the expression of p53 always preceded the specific arrest of cells in the G0/G1 phase. Interferon did not modulate down the expression of p53 if added to transformed non-induced Friend-erythroleukemia cells; however, it slightly enhanced the extent of reduction in p53 synthesis if added during cell differentiation, thus suggesting a differential effect of interferon between cells at different stages of differentiation. |
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Authors:
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R Ben-Dori; D Resnitzki; A Kimchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 162 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 384-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects Cell Transformation, Neoplastic Cells, Cultured Friend murine leukemia virus Interferon Type I / pharmacology Leukemia, Erythroblastic, Acute / metabolism* Leukemia, Experimental / metabolism* Mice Phosphoproteins / biosynthesis* Tumor Suppressor Protein p53 |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Phosphoproteins; 0/Tumor Suppressor Protein p53 |
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