Document Detail

Reduction in p53 synthesis during differentiation of Friend-erythroleukemia cells. Correlation with the commitment to terminal cell division.
MedLine Citation:
PMID:  6354748     Owner:  NLM     Status:  MEDLINE    
The process of cell differentiation in Friend-erythroleukemia cells was accompanied by 80-90% inhibition of p53 synthesis. This decrease was found to be linked to changes in cell-cycle distribution characteristics of the growth arrest program during differentiation rather than to the induction of the globin genes. The shut-off in the expression of p53 always preceded the specific arrest of cells in the G0/G1 phase. Interferon did not modulate down the expression of p53 if added to transformed non-induced Friend-erythroleukemia cells; however, it slightly enhanced the extent of reduction in p53 synthesis if added during cell differentiation, thus suggesting a differential effect of interferon between cells at different stages of differentiation.
R Ben-Dori; D Resnitzki; A Kimchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  162     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  384-9     Citation Subset:  IM    
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MeSH Terms
Cell Division / drug effects
Cell Transformation, Neoplastic
Cells, Cultured
Friend murine leukemia virus
Interferon Type I / pharmacology
Leukemia, Erythroblastic, Acute / metabolism*
Leukemia, Experimental / metabolism*
Phosphoproteins / biosynthesis*
Tumor Suppressor Protein p53
Reg. No./Substance:
0/Interferon Type I; 0/Phosphoproteins; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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