| Reduction in intestinal cholesterol absorption by various food components: Mechanisms and implications. | |
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MedLine Citation:
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PMID: 20439167 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A number of different food components are known to reduce plasma and LDL-cholesterol levels by affecting intestinal cholesterol absorption. They include: soluble fibers, phytosterols, saponins, phospholipids, soy protein and stearic acid. These compounds inhibit cholesterol absorption by affecting cholesterol solubilization in the intestinal lumen, interfering with diffusion of luminal cholesterol to the gut epithelium and/or inhibiting molecular mechanisms responsible for cholesterol uptake by the enterocyte. Cholesterol content of intestinal chylomicrons is subsequently reduced, less cholesterol is transported to the liver within chylomicron remnants, hepatic LDL-receptor activity is increased and plasma levels of LDL-cholesterol are decreased. Reduced hepatic VLDL production and less conversion of VLDL to LDL also contribute to lower LDL levels. Certain food components may also affect intestinal bile acid metabolism. Further investigation of the way in which these functional ingredients affect intestinal lipid metabolism will facilitate their use and application as cardiovascular nutraceuticals. |
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Authors:
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Jeffrey S Cohn; Alvin Kamili; Elaine Wat; Rosanna W S Chung; Sally Tandy |
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Publication Detail:
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Type: Journal Article Date: 2010-05-02 |
Journal Detail:
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Title: Atherosclerosis. Supplements Volume: 11 ISSN: 1878-5050 ISO Abbreviation: Atheroscler Suppl Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973461 Medline TA: Atheroscler Suppl Country: Netherlands |
Other Details:
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Languages: eng Pagination: 45-8 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2010. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St., Newtown, NSW 2042, Sydney, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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