| Reduction in infarct size following experimental coronary occlusion by administration of verapamil. | |
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MedLine Citation:
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PMID: 813284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of verapamil, a calcium antagonist and antiarrhythmic and anti-anginal actions, were studied on the size of infarct in open-chest anesthetized dogs with left anterior descending coronary artery occlusion. Hemodyamic functions were monitored by standard techniques, and infarct size was assessed by epicardial electrocardiography. Myocardial blood flow was measured by radioactive microspheres, and regional metabolism was studied by measuring lactate concentration in the venous drainage of the ischemic myocardium. Verapamil produced a significant reduction to ST segment elevation in the epicardial electrocardiogram and prevented the hemodynamic deterioration seen in the control animals in which ST segment elevation persisted. The drug had no effect on either total collateral blood flow or on the relative distribution of flow to the inner and outer halves of the ventricular wall. No significant differences were found between the levels of coronary venous lactate in the control animals and those in the verapamil-treated group. The results raise the possibility that the apparent protective effect of verapamil in myocardial ischemia may be due to its electrophysiological action on the cardiac membrane in relation to its calcium-antagonistic properites in excitable tissues. |
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Authors:
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B N Singh; H J Smith; R M Norris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Recent advances in studies on cardiac structure and metabolism Volume: 10 ISSN: 0363-5872 ISO Abbreviation: Recent Adv Stud Cardiac Struct Metab Publication Date: 1975 |
Date Detail:
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Created Date: 1976-04-01 Completed Date: 1976-04-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0325677 Medline TA: Recent Adv Stud Cardiac Struct Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 435-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Output / drug effects Coronary Circulation / drug effects Coronary Disease / drug therapy*, metabolism Disease Models, Animal Dogs Electrocardiography Electrophysiology Female Heart Rate / drug effects Hemodynamics / drug effects Lactates / biosynthesis Male Myocardial Infarction / pathology, physiopathology, prevention & control* Nitroglycerin / pharmacology Pressure Vascular Resistance / drug effects Verapamil / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 52-53-9/Verapamil; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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