Document Detail


Reduction in infarct size following experimental coronary occlusion by administration of verapamil.
MedLine Citation:
PMID:  813284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of verapamil, a calcium antagonist and antiarrhythmic and anti-anginal actions, were studied on the size of infarct in open-chest anesthetized dogs with left anterior descending coronary artery occlusion. Hemodyamic functions were monitored by standard techniques, and infarct size was assessed by epicardial electrocardiography. Myocardial blood flow was measured by radioactive microspheres, and regional metabolism was studied by measuring lactate concentration in the venous drainage of the ischemic myocardium. Verapamil produced a significant reduction to ST segment elevation in the epicardial electrocardiogram and prevented the hemodynamic deterioration seen in the control animals in which ST segment elevation persisted. The drug had no effect on either total collateral blood flow or on the relative distribution of flow to the inner and outer halves of the ventricular wall. No significant differences were found between the levels of coronary venous lactate in the control animals and those in the verapamil-treated group. The results raise the possibility that the apparent protective effect of verapamil in myocardial ischemia may be due to its electrophysiological action on the cardiac membrane in relation to its calcium-antagonistic properites in excitable tissues.
Authors:
B N Singh; H J Smith; R M Norris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  10     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Circulation / drug effects
Coronary Disease / drug therapy*,  metabolism
Disease Models, Animal
Dogs
Electrocardiography
Electrophysiology
Female
Heart Rate / drug effects
Hemodynamics / drug effects
Lactates / biosynthesis
Male
Myocardial Infarction / pathology,  physiopathology,  prevention & control*
Nitroglycerin / pharmacology
Pressure
Vascular Resistance / drug effects
Verapamil / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Lactates; 52-53-9/Verapamil; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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