Document Detail

Reduction in hyperglycemia by mild food restriction in streptozotocin induced diabetic rats improves insulin sensitivity.
MedLine Citation:
PMID:  7959606     Owner:  NLM     Status:  MEDLINE    
Hyperglycemia has been shown to contribute to the development and maintenance of insulin resistance in diabetic subjects and animal models of diabetes. Normalisation of circulating glucose levels is effective in restoring insulin action. The aim of the current study was to investigate the effects of mild food restriction on hyperglycemia in streptozotocin (STZ) treated (50 mg/kg) diabetic rats and to determine if the reductions in glycemia following food restriction were sufficient to alter insulin sensitivity. Food restriction was achieved in STZ diabetic and normal rats by limiting food access to two one-hourly meals daily and further in normal rats by restricting the feeding period to a single two-hour meal daily. Food intake was lowered by 39.7% (p < 0.01) in the food restricted STZ rats, without significant alteration in weight gain over 4 weeks. Similarly, in the normal rats once and twice daily meals lowered food intake by 37.6% and 21.6% when compared to the ad-libitum fed group, respectively. After 3 weeks food restriction in the STZ diabetic rats mean plasma glucose levels over a 12 hour period were reduced by 13.9%, glucose levels after a 6 hr fast were reduced by 33% (p < 0.05). Plasma insulin levels remained unaltered by food restriction. After 4 weeks food restriction in STZ diabetic rats basal glucose turnover was reduced (p < 0.05) and the metabolic clearance rate of glucose (MCR) increased (p < 0.05). During the hyperinsulinemic clamp hepatic glucose output (HGO) was suppressed and MCR elevated more effectively in the food restricted STZ than the ad-libitum STZ rats.(ABSTRACT TRUNCATED AT 250 WORDS)
D Cameron-Smith; G R Collier; K O'Dea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  26     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  316-21     Citation Subset:  IM    
School of Nutrition and Public Health, Deakin University, Geelong, Victoria, Australia.
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MeSH Terms
Blood Glucose / metabolism
Cholesterol / blood
Diabetes Mellitus, Experimental / blood*,  drug therapy
Food Deprivation*
Glucose Clamp Technique
Hyperglycemia / therapy*
Insulin / blood,  therapeutic use
Insulin Resistance*
Metabolic Clearance Rate
Rats, Sprague-Dawley
Triglycerides / blood
Weight Gain
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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