Document Detail

Reduction in cerebellar volumes in preterm infants: relationship to white matter injury and neurodevelopment at two years of age.
MedLine Citation:
PMID:  16690952     Owner:  NLM     Status:  MEDLINE    
A substantial number of prematurely born infants will experience later neurodevelopmental challenges. Abnormal development of the cerebellum may be related to some of the impairments exhibited by preterm children. To test the hypothesis that cerebellar development is structurally impaired in preterm infants and associated with adverse outcomes, we studied 83 preterm infants and 13 term controls using volumetric magnetic resonance imaging techniques to obtain cerebellar volumes (CV) at term corrected and subsequent neurodevelopmental assessment at 2 y of age. The preterm group had smaller mean CV at term compared with the term control infants [mean (SD) CV, 22.0 (5.0) versus 23.5 (5.0) cc; mean difference (95% confidence interval), 1.5 (-1.5, 4.4)] although this did not reach statistical significance. Within the preterm group, there was evidence of a reduction in CV related to the presence of white matter injury (WMI) after adjusting for intracranial volume (ICV) [WMI grade 1 versus grade 2: mean (SD) CV, 23.6 (5.0) versus 21.6 (4.5); p = 0.01; WMI grade 1 versus grade 3 and 4: 23.6 (5.0) versus 20.8 (5.6); p = 0.07]. Within the preterm infants, there was no apparent relationship between CV at term and gestational age at birth after adjusting for ICV. At 2 y of age, CV showed a weak correlation with cognitive and motor development, although this was principally mediated by WMI. In conclusion, we found no evidence for a primary impairment in cerebellar development in relation to prematurity, although there was evidence for a secondary effect of cerebral WMI on cerebellar development independent of immaturity.
Divyen K Shah; Peter J Anderson; John B Carlin; Masa Pavlovic; Kelly Howard; Deanne K Thompson; Simon K Warfield; Terrie E Inder
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-05-11
Journal Detail:
Title:  Pediatric research     Volume:  60     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-21     Completed Date:  2006-09-11     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Victoria Infant Brain Study Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
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MeSH Terms
Aging / pathology,  physiology
Cerebellum / anatomy & histology*,  growth & development,  pathology*
Child Development / physiology*
Child, Preschool
Cognition / physiology
Follow-Up Studies
Infant, Newborn
Infant, Premature / growth & development*,  physiology
Magnetic Resonance Imaging
Motor Activity / physiology
Nervous System / anatomy & histology,  growth & development*,  pathology
Organ Size
Psychomotor Performance / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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