| Reduction in arterial stiffness with angiotensin II antagonism and converting enzyme inhibition. A comparative study among malay hypertensive subjects with a known genetic profile. | |
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MedLine Citation:
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PMID: 17261465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Data comparing the effect of losartan and perindopril on aortic stiffness among hypertensive subjects without A(1166)C polymorphism was not available. METHODS: The short-term and long-term effects of losartan (50 mg) and perindopril (4 mg) on aortic stiffness measured as carotid femoral pulse wave velocity (PWV) were compared in 39 middle-aged Malay subjects with mild-to-moderate hypertension in a 4-month, double-blind, randomized, controlled, parallel-design study. RESULTS: Four-month treatment with both drugs showed a significant reduction in blood pressure (BP) (P < .005) and PWV (P < .05) as compared to the baseline. On the other hand 1-month treatment showed a significant reduction in BP only in perindopril group (P < .05) but not in the losartan group. There was no significant reduction in pulse pressure and PWV after 1 month treatment by both drugs. No significant difference was seen in reduction in BP after 1 month and 4 months treatment between the two drugs. Similarly no significant difference was seen in reduction in PWV between the two drugs after 1 month (P = .613) and 4 months (P = .521) of treatment. Reduction in PWV by losartan (r = 0.470) and perindopril (r = 0.457) correlated significantly only with reduction in DBP (P < .05) and remained significant even after controlling for reduction in DBP (P < .05). Reduction in PWV by both losartan and perindopril was independent of reduction in BP by these drugs. CONCLUSIONS: These results showed that long-term treatment with losartan shows similar pressure independent reduction in PWV as perindopril among Malay hypertensive subjects with a homogenous "AA" genotype for angiotensin II type 1 receptor and may serve as a suitable alternative to perindopril. |
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Authors:
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Asia Rehman; Shaiful Bahari Ismail; Lin Naing; Tariq Mahmood Roshan; Abdul Rashid Abdul Rahman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 20 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-30 Completed Date: 2007-05-07 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 184-9 Citation Subset: IM |
Affiliation:
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School of Dental Sciences, University Sains Malaysia, Kelantan, Malaysia. asia@kb.usm.my |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II Type 1 Receptor Blockers / therapeutic use* Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Aorta / drug effects*, physiopathology Double-Blind Method Female Humans Hypertension / drug therapy*, genetics, pathology Losartan / therapeutic use* Malaysia Male Perindopril / therapeutic use* Polymorphism, Genetic Pulse Receptor, Angiotensin, Type 1 / genetics |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptor, Angiotensin, Type 1; 114798-26-4/Losartan; 82834-16-0/Perindopril |
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