Document Detail


Reduction in MRSA environmental contamination with a portable HEPA-filtration unit.
MedLine Citation:
PMID:  16517004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is renewed interest in the hospital environment as a potentially important factor for cross-infection with methicillin-resistant Staphylococcus aureus (MRSA) and other nosocomial pathogens. The aim of this study was to evaluate the effectiveness of a portable high-efficiency particulate air (HEPA)-filtration unit (IQAir Cleanroom H13, Incen AG, Goldach, Switzerland) at reducing MRSA environmental surface contamination within a clinical setting. The MRSA contamination rate on horizontal surfaces was assessed with agar settle plates in ward side-rooms of three patients who were heavy MRSA dispersers. Contamination rates were measured at different air filtration rates (60-235 m(3)/h) and compared with no air filtration using Poisson regression. Without air filtration, between 80% and 100% of settle plates were positive for MRSA, with the mean number of MRSA colony-forming units (cfu)/10-h exposure/plate ranging from 4.1 to 27.7. Air filtration at a rate of 140 m(3)/h (one patient) and 235 m(3)/h (two patients), resulted in a highly significant decrease in contamination rates compared with no air filtration (adjusted rate ratios 0.037, 0.099 and 0.248, respectively; P < 0.001 for each). A strong association was demonstrated between the rate of air filtration and the mean number of MRSA cfu/10-h exposure/plate (P for trend < 0.001). In conclusion, this portable HEPA-filtration unit can significantly reduce MRSA environmental contamination within patient isolation rooms, and this may prove to be a useful addition to existing MRSA infection control measures.
Authors:
T C Boswell; P C Fox
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Publication Detail:
Type:  Journal Article     Date:  2006-03-03
Journal Detail:
Title:  The Journal of hospital infection     Volume:  63     ISSN:  0195-6701     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Nottingham City Hospital, UK. tboswell@ncht.trent.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Air Conditioning / instrumentation*
Air Microbiology
Air Pollutants / adverse effects*
Cross Infection / microbiology,  prevention & control*
Equipment Design
Equipment and Supplies, Hospital*
Filtration / instrumentation*
Health Facility Environment
Humans
Infection Control / methods*
Male
Methicillin Resistance*
Middle Aged
Staphylococcal Infections / prevention & control*
Staphylococcus aureus / drug effects,  isolation & purification,  pathogenicity*
Chemical
Reg. No./Substance:
0/Air Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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