Document Detail

Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents.
MedLine Citation:
PMID:  23207491     Owner:  NLM     Status:  Publisher    
Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function.
Patrícia Leão da Silva; Marco Túlio de Mello; Nadia Carla Cheik; Priscila Lima Sanches; Raquel Munhoz da Silveira Campos; June Carnier; Daniela Inoue; Claudia M O do Nascimento; Lila M Oyama; Lian Tock; Sérgio Tufik; Ana R Dâmaso
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Obesity facts     Volume:  5     ISSN:  1662-4033     ISO Abbreviation:  Obes Facts     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469429     Medline TA:  Obes Facts     Country:  -    
Other Details:
Languages:  ENG     Pagination:  806-820     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Post Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo, Brazil.
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