| Reduction in 28 Days and 6 Months of Acute Myocardial Infarction Mortality From 1995 to 2005. Data From PRIAMHO I, II and MASCARA Registries. | |
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MedLine Citation:
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PMID: 21803474 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION AND OBJECTIVES: To determine whether mortality from acute myocardial infarction has reduced in Spain and the possibly related therapeutic factors. METHODS: Nine thousand, nine hundred and forty-nine patients with ST-segment elevation myocardial infarction admitted to the Coronary Care Unit were identified from PRIAMHO I, II and MASCARA registries performed in 1995, 2000 and 2005, with a 6 month follow-up. RESULTS: From 1995 to 2005 patients were increasingly more likely to have hypertension, hyperlipidemia and anterior infarction, but age of onset and the proportion of females did not increase. Twenty-eight-day mortality rates were 12.6%, 12.3% and 6% in 1995, 2000 and 2005 respectively, and 15.3%, 14.6% and 9.4% at 6 months (both P-trend <.001). Multivariate analysis was performed and the adjusted odds ratio for 28-day mortality for an infarction occuring in 2005 (compared with 1995) was 0.62 (95% confidence interval: 0.44-0.88) whereas the adjusted hazard ratio for mortality at 6 months was 0.40 (95% confidence interval: 0.24-0.67). Other variables independently associated with lower mortality at 28 days were: reperfusion therapy, and the use of anti-thrombotic treatment, beta-blockers and angiotensin-converting enzyme inhibitors. The 28-day-6-month period had an independent protective effect on the following therapies: coronary reperfusion, and prescription of antiplatelet agents, beta-blockers and lipid lowering drugs upon discharge. CONCLUSIONS: Twenty-eight-day and six-month mortality rates fell among patients with ST-elevation myocardial infarction in Spain from 1995 to 2005. The possibly related therapeutic factors were the following: more frequent reperfusion therapy and increased use of anti-thrombotic drugs, beta-blockers, angiotensin-converting enzyme inhibitors and lipid lowering drugs. Full English text available from: www.revespcardiol.org. |
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Authors:
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Fernando Arós; Magda Heras; Joan Vila; Héctor Sanz; Ignacio Ferreira-González; Gaietà Permanyer-Miralda; José Cuñat; Lorenzo López-Bescós; Adolfo Cabadés; Angel Loma-Osorio; Jaume Marrugat; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-29 |
Journal Detail:
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Title: Revista espanola de cardiologia Volume: - ISSN: 1579-2242 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404277 Medline TA: Rev Esp Cardiol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Cardiología, Hospital Txagorritxu, José Atxotegi, s/n, 01009 Vitoria-Gasteiz, Álava, España. |
Vernacular Title:
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Reducción de la mortalidad precoz y a 6 meses en pacientes con IAM en el periodo 1995-2005. Datos de los registros PRIAMHO I, II y MASCARA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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