Document Detail


Reduction of food intake following X-ray irradiation of rats--involvement of visceral afferent nerves.
MedLine Citation:
PMID:  11958477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radiotherapy for malignant tumours often elicits anorexia or loss of appetite as an adverse effect. However, the mechanism for this is poorly understood. The present study was undertaken to investigate if visceral afferents are responsible for reduction of food intake following X-ray irradiation. Rats were exposed bilaterally to X-ray (10 MV) irradiation with total doses of 1.5, 3 and 6 Gy, using a high-energy electron linear accelerator at a dose rate of 4.9 Gy min(-1) X-ray irradiation of the whole body, abdomen or head with doses of 1.5, 3 and 6 Gy reduced food intake in a dose-dependent manner. The reduction of food intake after X-ray irradiation of the whole body or abdomen was significantly greater than when only the head was irradiated. Reduction of food intake was observed for the first 4 days after 6 Gy X-ray irradiation of the abdomen, while it was observed only on the first day after the same 6-Gy irradiation of the abdomen in animals whose small-diameter afferents were ablated by capsaicin pre-treatment. These results suggested that the abdominal afferent nerves at least contribute to the reduction of food intake observed on second to fourth days after 6-Gy abdominal irradiation. Taken together, the present evidence suggests that the reduction of food intake following X-ray irradiation of the whole body or the abdomen is partly mediated via abdominal afferent nerves. Moreover, the results of X-ray irradiation to the head suggest that X-ray irradiation directly influences the central nervous system to reduce food intake.
Authors:
Tatsuya Unno; Mitsuyasu Hashimoto; Shoichi Arai; Mieko Kurosawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  96     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-17     Completed Date:  2002-10-08     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Affiliation:
Basic Medical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Abdomen / radiation effects
Animals
Capsaicin / pharmacology
Eating / drug effects,  radiation effects*
Head / radiation effects
Male
Neurons, Afferent / physiology*
Rats
Rats, Wistar
Viscera / innervation*
Whole-Body Irradiation
Chemical
Reg. No./Substance:
404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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