Document Detail


Reduction of early ventricular arrhythmia by acebutolol in patients with acute myocardial infarction.
MedLine Citation:
PMID:  465240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effects of intravenously administered acebutolol (1-20 mg every 4 hours for 24 hours) on cardiac rhythm and performance, we studied 72 patients with evolving myocardial infarction. Twenty-five patients were treated with acebutolol beginning 6 hours after the first increase in the level of plasma creatine kinase. Enzymatically estimated infarct size was compared with that of 25 controls matched for predicted infarct size. Observed infarct sizes were not significantly different in the 2 groups (37 +/- 5 and 30 +/- 5 CK-gram equivalents, respectively). Mean heart rate, diastolic blood pressure, and cardiac output declined from control values during treatment with acebutolol, but remained within the normal range. Mean pulmonary artery pressure and pulmonary artery occlusive pressure were unchanged. In a group of 22 treated patients matched with 22 control subjects for frequency of ventricular extrasystoles, acebutolol effected a prompt reduction in frequencies of ventricular extrasystoles and repetitive arrhythmias, whereas values were not significantly changed in controls during the corresponding intervals. Accordingly, acebutolol may be a useful antiarrhythmic agent in selected patients with acute myocardial infarction with adversely altering haemodynamic stability or enzymatically estimated infarct size.
Authors:
G G Ahumada; R P Karlsberg; A S Jaffe; H D Ambos; B E Sobel; R Roberts
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British heart journal     Volume:  41     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  654-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acebutolol / therapeutic use*
Acute Disease
Adult
Aged
Arrhythmias, Cardiac / drug therapy*,  etiology
Creatine Kinase / blood
Electrocardiography
Female
Hemodynamics
Humans
Male
Middle Aged
Myocardial Infarction / complications,  drug therapy*,  enzymology,  physiopathology
Chemical
Reg. No./Substance:
37517-30-9/Acebutolol; EC 2.7.3.2/Creatine Kinase
Comments/Corrections

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