| Reduction of drug leakage by negative-balance isolated pelvic perfusion: correlation between leakage and in-out flow rate in a pig model. | |
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MedLine Citation:
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PMID: 15895252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Isolated pelvic perfusion (IPP) therapy exposes target tissues to high doses of anticancer drugs with low systemic concentrations, but the major drawback is drug leakage into the systemic circulation, which often thwarts the increased drug concentration. In this study, the efficacy of altering the in-out flow rate during IPP in order to decrease the leakage was assessed in adult pigs. METHODS: The abdominal aorta and the infrarenal vena cava were occluded with two balloon catheters, blood in the extracorporeal circuit was circulated with twin rotary pumps, and the IPP was performed with platinum. Three sets of in-out flow rates were used, and the degree of drug leakage into the systemic circulation was evaluated. The volume of blood withdrawn was equal to the volume returned (300 ml/min; group A), 5% higher (group B), or 10% higher (group C). The platinum concentrations in the pelvic circulation, systemic circulation, and urine were measured and compared. RESULTS: The average and maximum plasma platinum concentrations in the pelvic circulation did not significantly differ among the three groups. The plasma platinum concentrations in the systemic venous circulation of the three groups significantly (P<0.01) decreased as the volume withdrawn during IPP increased. The percentage of platinum eliminated in the urine during IPP was significantly (P<0.01) lower in group B and C than in group A. CONCLUSIONS: Setting the volume withdrawn higher than the volume returned decreased leakage into the systemic circulation under isolated pelvic perfusion. |
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Authors:
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Satoru Murata; Hiroyuki Tajima; Gen-ichi Kusakai; Tatsuo Kumazaki; Yutaka Abe; Shiro Onozawa; Yasushige Komada; Yukihiro Kondo; Ryoji Kimata; Seiichiro Himeno; Mitsuo Satake |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-20 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 131 ISSN: 0171-5216 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-27 Completed Date: 2006-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 575-80 Citation Subset: IM |
Affiliation:
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Department of Radiology/Center for Advanced Medical Technology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, Tokyo, 113-8602, Japan. murata_satoru@nms.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Animals Antineoplastic Agents / administration & dosage*, analysis, pharmacokinetics Blood Circulation Chemotherapy, Cancer, Regional Perfusion / methods* Male Models, Biological Pelvis / blood supply* Platinum / administration & dosage*, analysis, pharmacokinetics Regional Blood Flow Swine |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 7440-06-4/Platinum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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