| Reduction of cytochrome c by hydrogen peroxide and its inhibition by superoxide dismutase. | |
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MedLine Citation:
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PMID: 6299288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ferricytochrome c is slowly converted by hydrogen peroxide to an equilibrium mixture of ferricytochrome c and ferrocytochrome c, and in the process, the hydrogen peroxide is decomposed. The reductant appears to be superoxide anion, produced from the reaction of hydrogen peroxide with oxygen. Because the reduction of ferricytochrome c by hydrogen peroxide is inhibited by superoxide dismutase, we propose that the enzyme acts by converting superoxide anion to a dimerized product that is less active as a reductant. |
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Authors:
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C Bernofsky; S Y Wanda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 111 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemical Phenomena Chemistry Cytochrome c Group / metabolism* Hydrogen Peroxide / metabolism* Oxidation-Reduction Superoxide Dismutase / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL-24192/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytochrome c Group; 7722-84-1/Hydrogen Peroxide; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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