| Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. | |
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MedLine Citation:
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PMID: 16736065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to evaluate the efficacy on crying episodes owing to infantile colic of a new infant formula containing partially hydrolysed whey proteins, prebiotic oligosaccharides (OS), with a high beta-palmitic acid content. DESIGN: Prospective randomized controlled study. SETTING: Italy. SUBJECTS: Two hundred and sixty-seven formula-fed infants, aged less than 4 months, with infantile colic, were randomized to receive either the new infant formula (study treatment (ST)) or a standard formula and simethicone (6 mg/kg twice a day) (control treatment (CT)). A questionnaire was given to parents to evaluate for 14 days the daily number of colic episodes and crying time. RESULTS: Out of the 199 infants who completed the study, 96 were treated with the new formula and 103 were not treated. Infants receiving the new formula had a significant decrease in colic episodes after 1 week (2.47+/-1.94 at day 7 vs 5.99+/-1.84 at the study entry) compared to infants receiving the CT (3.72+/-1.98 at day 7 vs 5.41+/-1.88 at the study entry) (P < 0.0001). Also at day 14, the crying episodes were significantly different between the two groups of infants (1.76+/-1.60 in ST vs 3.32+/-2.06 in CT) (P < 0.0001). CONCLUSIONS: The use of a partially hydrolysed formula supplemented with fructo- and galacto-OS induces a reduction of crying episodes in infants with colic after 7 and 14 days when compared with a standard formula and simethicone. |
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Authors:
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F Savino; E Palumeri; E Castagno; F Cresi; P Dalmasso; F Cavallo; R Oggero |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-05-31 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 60 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2007-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1304-10 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of Turin, Turin, Italy. francesco.savino@unito.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colic
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diet therapy*,
epidemiology Crying Dietary Proteins / therapeutic use* Emollients / therapeutic use Female Humans Infant Infant Formula* Infant, Newborn Male Milk Proteins / therapeutic use Oligosaccharides / therapeutic use Palmitic Acid / therapeutic use* Prospective Studies Protein Hydrolysates / therapeutic use* Simethicone / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Emollients; 0/Milk Proteins; 0/Oligosaccharides; 0/Protein Hydrolysates; 0/whey protein; 57-10-3/Palmitic Acid; 8050-81-5/Simethicone |
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