Document Detail


Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.
MedLine Citation:
PMID:  22534819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current study tested the hypothesis that conditioned pain modulation is mediated by the release of endogenous opioids with a placebo-controlled (sugar pill) study of naltrexone (50 mg) in 33 healthy volunteers over two counter-balanced sessions. Pain modulation consisted of rating of heat pain (palm) during concurrent cold water immersion (foot). Compared to baseline heat pain ratings, concurrent foot immersion lowered pain intensity ratings, which suggests an inhibitory effect, was reduced with naltrexone, suggesting at least partial dependence of inhibition on endogenous opioids. An exploratory analysis revealed that individual differences in catastrophizing moderated the effects of naltrexone; endogenous opioid blockade abolished modulation in subjects lower in catastrophizing while modulation was unaffected by naltrexone among high catastrophizers. The results suggest a role of endogenous opioids in endogenous analgesia, but hint that multiple systems might contribute to conditioned pain modulation, and that these systems might be differentially activated as a function of individual differences in responses to pain.
Authors:
Christopher D King; Burel Goodin; Lindsay L Kindler; Robert M Caudle; Robert R Edwards; Nikolaus Gravenstein; Joseph L Riley; Roger B Fillingim
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-26
Journal Detail:
Title:  Journal of behavioral medicine     Volume:  36     ISSN:  1573-3521     ISO Abbreviation:  J Behav Med     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-08     Completed Date:  2013-10-17     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7807105     Medline TA:  J Behav Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Catastrophization / physiopathology*,  psychology*
Conditioning, Classical / drug effects*,  physiology*
Cross-Over Studies
Diffuse Noxious Inhibitory Control / drug effects*,  physiology*
Double-Blind Method
Female
Humans
Individuality
Male
Naltrexone / pharmacology*
Narcotic Antagonists / pharmacology*
Opioid Peptides / physiology
Pain / physiopathology*,  psychology*
Pain Threshold / drug effects,  physiology
Young Adult
Grant Support
ID/Acronym/Agency:
L30 AG040467/AG/NIA NIH HHS; R01 AG034982/AG/NIA NIH HHS; R21 AR057920/AR/NIAMS NIH HHS; T32 DE007200/DE/NIDCR NIH HHS; T32 NS045551/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Narcotic Antagonists; 0/Opioid Peptides; 5S6W795CQM/Naltrexone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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