Document Detail


Reduction of common synaptic drive to ankle dorsiflexor motoneurons during walking in patients with spinal cord lesion.
MedLine Citation:
PMID:  15800077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is possible to obtain information about the synaptic drive to motoneurons during walking by analyzing motor-unit coupling in the time and frequency domains. The purpose of the present study was to compare motor-unit coupling during walking in healthy subjects and patients with incomplete spinal cord lesion to obtain evidence of differences in the motoneuronal drive that result from the lesion. Such information is of importance for development of new strategies for gait restoration. Twenty patients with incomplete spinal cord lesion (SCL) participated in the study. Control experiments were performed in 11 healthy subjects. In all healthy subjects, short-term synchronization was evident in the discharge of tibialis anterior (TA) motor units during the swing phase of treadmill walking. This was identified from the presence of a narrow central peak in cumulant densities constructed from paired EMG recordings and from the presence of significant coherence between these signals in the 10- to 20-Hz band. Such indicators of short-term synchrony were either absent or very small in the patient group. The relationship between the amount of short-term synchrony and the magnitude of the 10- to 20-Hz coherence in the patients is discussed in relation to gait ability. It is suggested that supraspinal drive to the spinal cord is responsible for short-term synchrony and coherence in the 10- to 20-Hz frequency band during walking in healthy subjects. Absence or reduction of these features may serve as physiological markers of impaired supraspinal control of gait in SCL patients. Such markers could have diagnostic and prognostic value in relation to the recovery of locomotion in patients with central motor lesions.
Authors:
N L Hansen; B A Conway; D M Halliday; S Hansen; H S Pyndt; F Biering-Sørensen; J B Nielsen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-30
Journal Detail:
Title:  Journal of neurophysiology     Volume:  94     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  934-42     Citation Subset:  IM    
Affiliation:
Department of Physical Exercise and Sport Science and Division of Neurophysiology, The Panum Institute, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology,  radiation effects
Adult
Ankle / physiology*
Electric Stimulation / methods
Electromyography / methods
Exercise Test / methods
Female
Fourier Analysis
Gait / physiology
Humans
Male
Middle Aged
Motor Neurons / physiology*,  radiation effects
Muscle Contraction / physiology,  radiation effects
Muscle, Skeletal / physiology*,  radiation effects
Reaction Time / physiology,  radiation effects
Reflex, Stretch / physiology*,  radiation effects
Sensory Thresholds / physiology,  radiation effects
Spinal Cord Injuries / physiopathology*
Walking / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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