Document Detail

Reduction of carotid arterial blood flow in ventricular septal defect associated with severe congestive heart failure.
MedLine Citation:
PMID:  11147409     Owner:  NLM     Status:  MEDLINE    
After diagnosing abnormality of cardiac and carotid-cerebral circulation in an infant with isolated ventricular septal defect (VSD) associated with severe congestive heart failure, the authors measured the carotid arterial blood flow volume (CABF). At 3 months, the patient was not thriving and had dyspnea because of severe congestive heart failure. The authors measured the VSD size/body surface area (BSA) ratio relative to the predicted value of the left ventricular end-diastolic dimension (%LVEDd), left-to-right shunt ratio (Qp/Qs), and the small stroke volume (SV)/BSA using echocardiography and cardiac catheterization. The mean, maximum, and minimum CABF (mean CABF, maxCABF, and minCABF) among R-R intervals on electrocardiogram were measured by Doppler flowmetry in this patient and 5 healthy age-matched control children. The patient had a large VSD size/BSA ratio (37.9 mm/m2), %LVEDd (164%), and Qp/Qs (3.8), and a small SV/BSA ratio (18 mL/m2). The mean CABF, maxCABF, and minCABF were significantly lower than those of control children (VSD patient vs. controls; 2.7 +/- 0.4 vs. 4.5 +/- 0.6, 6.1 +/- 0.9 vs. 12.0 +/- 2.1, 1.2 +/- 0.2 vs. 1.7 +/- 0.4 mL/sec (mean +/- S.D.)), respectively (p < 0.01). The authors' results showed abnormal cardiac and carotid-cerebral circulation in an infant with large VSD associated with severe congestive heart failure.
M Kojo; K Yamada; S Akiyoshi; M Maeda; K Sato; T Izumi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  10     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-09     Completed Date:  2000-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
Department of Pediatrics, Oita Medical University, School of Medicine, Oita, Japan.
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MeSH Terms
Blood Volume / physiology
Body Surface Area
Carotid Arteries / physiopathology*
Case-Control Studies
Cerebrovascular Circulation / physiology
Coronary Circulation / physiology
Failure to Thrive / physiopathology
Heart Catheterization
Heart Failure / physiopathology*
Heart Septal Defects, Ventricular / physiopathology*
Heart Ventricles / pathology
Regional Blood Flow / physiology
Stroke Volume / physiology
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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