Document Detail


Reduction of calculus accumulation in domestic ferrets with two dentifrices containing pyrophosphate.
MedLine Citation:
PMID:  2155258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Work performed by King et al. in the 1940's and 1950's, as well as recent studies by our group, have shown that the domestic ferret is a suitable model for the study of calculus formation, offering several advantages over the rodent and dog models in current use. We have demonstrated that mineral supplementation of a moist diet accelerates calculus accumulation, and that twice-daily application of a regular dentifrice slows the initial rate of calculus formation, but permits significant accumulation by the eighth week. The present study compared calculus accumulation in female ferrets receiving mineral-supplemented cat food and a twice-daily application of either Regular Crest toothpaste (Crest), Anti-tartar Crest (Crest-AT), or Anti-tartar Colgate Gold toothpaste (Colg-AT). Animals received an ultrasonic prophylaxis, then were fed once daily for eight weeks with moist canned cat food supplemented with sucrose and mineral salts, and were scored for area and extent of calculus accumulation at four and eight weeks after prophylaxis. The data show that the groups treated with the anti-calculus dentifrices produced significantly less calculus than the group treated with regular dentifrice; the Colg-AT group also exhibited lower scores than did the Crest-AT group, especially at four weeks. These results, similar to those seen in human studies, demonstrate that the ferret is a suitable model for the study of anti-calculus dentifrices.
Authors:
P H Mann; D S Harper; S Regnier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of dental research     Volume:  69     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-02     Completed Date:  1990-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-3     Citation Subset:  D; IM    
Affiliation:
Fairleigh Dickinson University, Oral Health Research Center, Hackensack, New Jersey 07601.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Carnivora*
Dental Calculus / drug therapy*
Dentifrices / therapeutic use*
Diet, Cariogenic
Diphosphates / therapeutic use*
Disease Models, Animal*
Female
Ferrets*
Minerals / pharmacology
Sucrose / pharmacology
Toothpaste / therapeutic use*
Chemical
Reg. No./Substance:
0/Dentifrices; 0/Diphosphates; 0/Minerals; 0/Toothpaste; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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