Document Detail

Reduction of calculus accumulation in domestic ferrets with two dentifrices containing pyrophosphate.
MedLine Citation:
PMID:  2155258     Owner:  NLM     Status:  MEDLINE    
Work performed by King et al. in the 1940's and 1950's, as well as recent studies by our group, have shown that the domestic ferret is a suitable model for the study of calculus formation, offering several advantages over the rodent and dog models in current use. We have demonstrated that mineral supplementation of a moist diet accelerates calculus accumulation, and that twice-daily application of a regular dentifrice slows the initial rate of calculus formation, but permits significant accumulation by the eighth week. The present study compared calculus accumulation in female ferrets receiving mineral-supplemented cat food and a twice-daily application of either Regular Crest toothpaste (Crest), Anti-tartar Crest (Crest-AT), or Anti-tartar Colgate Gold toothpaste (Colg-AT). Animals received an ultrasonic prophylaxis, then were fed once daily for eight weeks with moist canned cat food supplemented with sucrose and mineral salts, and were scored for area and extent of calculus accumulation at four and eight weeks after prophylaxis. The data show that the groups treated with the anti-calculus dentifrices produced significantly less calculus than the group treated with regular dentifrice; the Colg-AT group also exhibited lower scores than did the Crest-AT group, especially at four weeks. These results, similar to those seen in human studies, demonstrate that the ferret is a suitable model for the study of anti-calculus dentifrices.
P H Mann; D S Harper; S Regnier
Related Documents :
18598588 - Intake and status of folate and related b-vitamins: considerations and challenges in ac...
11348558 - Influence of folic acid-fortified foods on folate status in a folate depletion-repletio...
17521468 - Validation of a food frequency questionnaire to assess folate intake of dutch elderly p...
17683648 - Awareness and consumption of folate-fortified foods by women of childbearing age in wes...
21338558 - Food and drink intake during television viewing in adolescents: the healthy lifestyle i...
6008198 - An indirect method to assay for mitotic centers in sand dollar (dendraster excentricus)...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of dental research     Volume:  69     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-02     Completed Date:  1990-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-3     Citation Subset:  D; IM    
Fairleigh Dickinson University, Oral Health Research Center, Hackensack, New Jersey 07601.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Dental Calculus / drug therapy*
Dentifrices / therapeutic use*
Diet, Cariogenic
Diphosphates / therapeutic use*
Disease Models, Animal*
Minerals / pharmacology
Sucrose / pharmacology
Toothpaste / therapeutic use*
Reg. No./Substance:
0/Dentifrices; 0/Diphosphates; 0/Minerals; 0/Toothpaste; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG def...
Next Document:  Cellular uptake of conjugated bilirubin and sulfobromophthalein (BSP) by the human hepatoma cell lin...