Document Detail

Reduction by 9-tetrahydrocannabinol in the blood pressure of hypertensive rats bearing regenerated adrenal glands.
MedLine Citation:
PMID:  4724188     Owner:  NLM     Status:  MEDLINE    
A suspension of (-)-Delta(9)-trans-tetrahydrocannabinol (Delta(9)-THC) (3 mg/kg body wt) was administered daily for one week by i.p. injection to female rats showing the syndrome of adrenal regeneration hypertension (ARH). Other ARH rats received no injections or injections of vehicle only. On the first day, Delta(9)-THC decreased the average blood pressure by 38+/-6 mmHg 1 h, 31+/-5 mmHg 3 h, and 11+/-5 mmHg 5 h after injection (n=0). On subsequent days the acute effect disappeared, but statistically highly significant decreases were observed between the blood pressures of the Delta(9)-THC-treated group and those of the other two groups. Plasma corticosterone concentrations, measured on the eighth day of treatment, one hour after injection time, averaged 26.+/-2.7 mug/100 ml in the untreated animals, 26.6+/-2.0 mug/100 ml in the vehicle-injected animnals, and 21.3+/-2.4 mug/100 ml in the animals injected with Delta(9)-THC. The findings indicate that Delta(9)-THC, at a moderate dose for the rat, is capable of lowering the blood pressure in rats suffering from adrenal regeneration hypertension and that chronic administration of Delta(9)-THC does not appear to stimulate the pituitary-adrenal axis, in contrast to reported effects of acute administration (Barry, Perhach & Kubena, 1970).
M K Birmingham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  48     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1973 May 
Date Detail:
Created Date:  1973-10-12     Completed Date:  1973-10-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / physiology*
Blood Pressure / drug effects*
Cannabis / pharmacology*
Corticosterone / blood
Hypertension / genetics
Tetrahydrocannabinol / pharmacology
Time Factors
Reg. No./Substance:
1972-08-3/Tetrahydrocannabinol; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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