Document Detail

Reduction of bronchial responsiveness to methacholine after mitral valve replacement.
MedLine Citation:
PMID:  1862255     Owner:  NLM     Status:  MEDLINE    
Sixteen patients with mitral valve disease, in whom bronchial hyperresponsiveness to methacholine had been detected shortly before mitral valve replacement (MVR), were reevaluated 35 +/- 1.5 months after MVR. In 9/16 patients there was a significant (greater than 1.5 fold) increase in bronchial provocation dose of methacholine (PD20FEV1) after MVR. In the same patients there was a significant increase in vital capacity (from 69.6 +/- 5 to 75.8 +/- 5.2% of predicted, p less than 0.01), a significant decrease in cardiothoracic ratio and in radiologic score for lung edema (from 64.3 +/- 2.9 to 56 +/- 2.1, p less than 0.01 and from 38 +/- 4.5 to 14.6 +/- 2, p less than 0.001, respectively). In all the patients the increase in PD20FEV1 was not related to any change in spirometric values but it was related to the decrease in cardiothoracic index (r = 0.72, p less than 0.01) and in radiologic score for lung edema (r = 0.61, p less than 0.05) observed after cardiosurgery.
G Rolla; C Bucca; L Brussino; P Costa; M Morea
Related Documents :
3168345 - Mitral annular calcification and coarctation of aorta.
8340585 - Reevaluation of plain radiographic findings in the diagnosis of aortic rupture: the rol...
2934255 - Echocardiographic assessment of cardiac function and morphology in patients with genera...
3592835 - Hypothermic circulatory arrest in the treatment of thoracic aortic lesions.
2589385 - Efficacy and safety of higher-dose intravenous ciprofloxacin in severe hospital-acquire...
15922265 - Scar-related right atrial macroreentrant tachycardia in patients without prior atrial s...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  58     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Clinica Medica I dell'Università di Torino, Italia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchial Provocation Tests
Bronchoconstriction / drug effects*,  physiology
Dose-Response Relationship, Drug
Forced Expiratory Volume / physiology
Heart Valve Prosthesis*
Maximal Expiratory Flow-Volume Curves / physiology
Methacholine Chloride / administration & dosage,  pharmacology*
Middle Aged
Mitral Valve / surgery*
Reproducibility of Results
Vital Capacity / physiology
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bronchoalveolar lavage: comparison of three commonly used procedures.
Next Document:  Circulatory response to repeated exercise in patients with chronic lung disease.