Document Detail


Reduction of bronchial responsiveness to methacholine after mitral valve replacement.
MedLine Citation:
PMID:  1862255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixteen patients with mitral valve disease, in whom bronchial hyperresponsiveness to methacholine had been detected shortly before mitral valve replacement (MVR), were reevaluated 35 +/- 1.5 months after MVR. In 9/16 patients there was a significant (greater than 1.5 fold) increase in bronchial provocation dose of methacholine (PD20FEV1) after MVR. In the same patients there was a significant increase in vital capacity (from 69.6 +/- 5 to 75.8 +/- 5.2% of predicted, p less than 0.01), a significant decrease in cardiothoracic ratio and in radiologic score for lung edema (from 64.3 +/- 2.9 to 56 +/- 2.1, p less than 0.01 and from 38 +/- 4.5 to 14.6 +/- 2, p less than 0.001, respectively). In all the patients the increase in PD20FEV1 was not related to any change in spirometric values but it was related to the decrease in cardiothoracic index (r = 0.72, p less than 0.01) and in radiologic score for lung edema (r = 0.61, p less than 0.05) observed after cardiosurgery.
Authors:
G Rolla; C Bucca; L Brussino; P Costa; M Morea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  58     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Affiliation:
Clinica Medica I dell'Università di Torino, Italia.
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MeSH Terms
Descriptor/Qualifier:
Bronchial Provocation Tests
Bronchoconstriction / drug effects*,  physiology
Dose-Response Relationship, Drug
Forced Expiratory Volume / physiology
Heart Valve Prosthesis*
Humans
Maximal Expiratory Flow-Volume Curves / physiology
Methacholine Chloride / administration & dosage,  pharmacology*
Middle Aged
Mitral Valve / surgery*
Reproducibility of Results
Spirometry
Vital Capacity / physiology
Chemical
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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