| Reduction of body weight, liver steatosis and SCD1 expression by pharmacologic administration of the isoflavone daidzein in diet-induced obesity. | |
| | |
MedLine Citation:
|
PMID: 21557739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and purpose. The lack of safe and effective approved drugs against obesity has raised a great interest on natural products that may serve as alternative therapies. From this perspective we have addressed the analysis of the effects of daidzein, one of the main soy isoflavones, on diet induced obesity in rats. Experimental approach. Rats made obese after exposure to a very (60%) high fat content diet were treated with Daidzein (50 mg/kg) for 14 days. The dose was selected on the basis of the acute effects of this isoflavone on a feeding test. After 14 days, animals were sacrificed and plasma, white and brown adipose tissues, muscle and liver studied for the levels and expression of metabolites, proteins and genes relevant for lipid metabolism. Key results. Acute daidzein dose-dependently reduced food intake. Chronic treatment reduced weight gain and reduced fat content in the liver. This was associated with high leptin levels and low adiponectin contents in plasma. While skeletal muscle was weakly affected by treatment, both adipose tissue and liver displayed marked changes induced by daidzein that affect transcription factors and lipogenic enzymes, specially stearoyl coenzyme A desaturase-1, a pivotal enzyme in obesity. Protein expression of the uncoupling protein 1, an important enzyme involved in thermogenesis, was increased in brown adipose tissue after daidzein treatment. Conclusions and implications. These results give support to the use of isoflavones in diet induced obesity, especially when hepatic steatosis is present, opening a new field of use for these natural products. |
| | |
Authors:
|
A Crespillo; M Alonso; M Vida; F J Pavón; A Serrano; P Rivera; Y Romero-Zerbo; P Fernández-Llebrez; A Martínez; V Pérez-Valero; F J Bermúdez-Silva; J Suárez; F Rodríguez de Fonseca |
Related Documents
:
|
12927739 - Retrospective analysis: bile hydrocarbons and histopathology of demersal rockfish in pr... 15567939 - High-fat corn oil diet promotes the development of high histologic grade rat dmba-induc... 2145499 - A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. 2534319 - Effect of age on the modification of brain polyunsaturated fatty acids and enzyme activ... 18649029 - Regulation of growth, fatty acid composition and delta 6 desaturase expression by dieta... 12557909 - Effect of excessive intake of thermally oxidized sesame oil on lipids, lipid peroxidati... 2757799 - Dietary nacl loading enhances antihypertensive effect of guanabenz in spontaneously hyp... 19043049 - Digestive physiology of the burmese python: broad regulation of integrated performance. 15635349 - Chitosan supplementation and fat absorption in men and women. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-10 |
Journal Detail:
|
Title: British journal of pharmacology Volume: - ISSN: 1476-5381 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
|
Laboratorio de Medicina Regenerativa, Hospital Carlos Haya, Fundación IMABIS, Avda. Carlos Haya 82, Pabellón de Gobierno, 29010, Málaga, Spain. Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, 29071, Málaga, Spain. Institute of Medical Chemistry, the Spanish National Research Council (CSIC), Madrid 28006, Spain. Laboratorio de Bioquímica, Hospital Carlos Haya, Avda. Carlos Haya 82, Pabellón B, 29010, Málaga, Spain. CIBER OBN, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, 28029, Madrid, Spain. Neurocentre Magendie, Inserm U862, 33077, Bordeaux, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The flavonoid scaffold as a template for the design of vascular Ca(v) 1.2 channels modulators.
Next Document: Longitudinal Associations Between Marital Instability and Child Sleep Problems Across Infancy and To...