Document Detail

Reduction of blood pressure retards the progression of chronic renal failure in man.
MedLine Citation:
PMID:  3146719     Owner:  NLM     Status:  MEDLINE    
The effect of blood pressure reduction on the progression rate of chronic renal failure (CRF) was studied in 28 patients with CRF of diverse aetiology entering a prospective study (observation time 7-24 months, mean 16 months). Endogenous creatinine clearance was 12-66 ml/min (mean 30 +/- 3 ml/min). We aimed to keep the blood pressure below 160/90 mmHg. Dietary protein was not restricted. The progression rate of CRF was assessed from the regression coefficients of the regressions of creatinine clearance and the inverse of s-creatinine, respectively, on time. Progression rate and the means of all recordings of mean arterial blood pressure (MAP) and urinary protein excretion, respectively, in each patient during the prospective phase were compared with retrospective data from the proceeding period (observation time 4-25 months, mean 19 months). The patients received various combinations of antihypertensive drugs including diuretics, beta-blockers and vasodilatory drugs. In 19 patients MAP decreased from 109 +/- 2 to 102 +/- 2 mmHg (group I), whereas MAP increased from 105 +/- 2 to 108 +/- 2 mmHg in nine patients (group II). In group I proteinuria was significantly lower (P less than 0.05) and the progression of CRF was approximately 50% slower (P less than 0.01) in the prospective phase than in the retrospective phase; no changes were observed in group II. Calculated for all patients, significant correlations were observed between the change in MAP and the change in progression rate and protein excretion, respectively. These results indicate that lowering of blood pressure results in decreased proteinuria and retardation of the progression of CRF irrespective of the aetiology.
A Alvestrand; A Gutierrez; H Bucht; J Bergström
Related Documents :
1327379 - Effects of hoe 140, a bradykinin b2-receptor antagonist, on renal function in conscious...
24954709 - Use of pressure-volume conductance catheters in real-time cardiovascular experimentation.
1343279 - Clinical evaluation of the efficacy and safety of manidipine in hypertensive patients w...
8558479 - The effects of systemic hypoxia on renal function in the anaesthetized rat.
10212379 - Is greater than normal nocturnal heart rate in children with renal scars a predictor of...
19846849 - Strict blood-pressure control and progression of renal failure in children.
2851039 - Effects of the angiotensin converting enzyme inhibitor enalapril compared with diuretic...
6460889 - The hypotensive mechanisms of the new anti-anginal drug, n-(2-hydroxyethyl)nicotinamide...
8829819 - Hypertension from carotid occlusion decreases renal papillary plasma flow, hypotension ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  3     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-14     Completed Date:  1989-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  624-31     Citation Subset:  IM    
Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Creatinine / urine
Follow-Up Studies
Kidney Failure, Chronic / drug therapy*,  urine
Middle Aged
Prospective Studies
Proteinuria / drug therapy,  urine
Retrospective Studies
Reg. No./Substance:
0/Antihypertensive Agents; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enhanced gastrointestinal absorption of aluminium in uraemia: time course and effect of vitamin D.
Next Document:  Tissue uptake of 125I-beta 2-microglobulin (beta 2-M) in anephric animals in the presence or absence...