Document Detail

Reduction of blood loss using high-dose aprotinin in major orthopaedic surgery: a prospective, double-blind, randomised and placebo-controlled study.
MedLine Citation:
PMID:  12678347     Owner:  NLM     Status:  MEDLINE    
We have investigated in a prospective,randomised placebo-controlled study the effect of high-dose aprotinin on blood loss in patients admitted for major surgery (revision arthroplasty of the hip or knee, or for resection of a soft-tissue sarcoma). The mean intraoperative blood loss was reduced from 1957 ml in the control group to 736 ml in the aprotinin group (p = 0.002). The mean requirement for intraoperative homologous blood transfusion in the aprotinin group was 1.4 units (95% CI 0.2 to 2.7) and 3.1 units (95% CI 1.7 to 4.6) in the control group (p = 0.033). The mean length of hospital stay was reduced from 27.8 days in the control group to 17.6 days in the aprotinin group which was not statistically significant. The intraoperative use of aprotinin in major orthopaedic operations significantly reduced blood loss and the required amount of packed cells. It may result in in the length of hospital stay and costs.
R Jeserschek; H Clar; C Aigner; P Rehak; B Primus; R Windhager
Related Documents :
20406227 - What measured blood loss tells us about postpartum bleeding: a systematic review.
18773097 - Open hepatic parenchymal transection using ultrasonic dissection and bipolar coagulation.
7056057 - Hypotension during surgery for subdural hematoma and effusion in infants.
6517267 - Initial assessment of acute haemorrhage.
12897037 - Selected contribution: aging impairs nitric oxide and prostacyclin mediation of endothe...
11903147 - Initial management of severe hemorrhage with an oxygen-carrying hypertonic saline solut...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  85     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-07     Completed Date:  2003-04-24     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-7     Citation Subset:  AIM; IM    
Department of Orthopaedics, Karl-Franzens University School of Medicine, Graz, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Aprotinin / therapeutic use*
Blood Loss, Surgical / prevention & control*
Blood Transfusion
Double-Blind Method
Hemostasis, Surgical / methods
Hemostatics / therapeutic use*
Intraoperative Care / methods
Length of Stay
Middle Aged
Orthopedic Procedures*
Prospective Studies
Serine Proteinase Inhibitors / therapeutic use
Reg. No./Substance:
0/Hemostatics; 0/Serine Proteinase Inhibitors; 9087-70-1/Aprotinin
Comment In:
J Bone Joint Surg Br. 2004 May;86(4):620; author reply 620-1   [PMID:  15174566 ]
J Bone Joint Surg Br. 2004 Mar;86(2):309-10; author reply 310   [PMID:  15046454 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Turn-up bone flap for lengthening the below-knee amputation stump.
Next Document:  Effect of smoking on early complications after elective orthopaedic surgery.