| Reduction of arteriosclerotic nanoplaque formation and size by n-3 fatty acids in patients after valvular defect operation. | |
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MedLine Citation:
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PMID: 19729934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/METHODS: Coating a silica surface with the isolated lipoprotein receptor heparan sulfate proteoglycan (HS-PG) from arterial endothelium and vascular matrices, we could observe the very earliest stages of arteriosclerotic plaque development by ellipsometric techniques in vitro (patent EP 0 946 876). This so-called nanoplaque formation is represented by the ternary aggregational complex of the HS-PG receptor, lipoprotein particles and calcium ions. The model was validated in several clinical studies on statins in cardiovascular high-risk patients applying their native blood lipoprotein fractions. RESULTS: In 7 patients who had undergone a valvular defect operation, the reduction of arteriosclerotic nanoplaque formation in normal Krebs solution amounted to 6.1 +/- 2.3% (p < 0.0156) and of nanoplaque size to 37.5 +/- 13.2% (p < 0.0312), respectively, after a 3-month therapy with n-3 fatty acids (3 ..3 g daily, Ameu 500 mg). Additionally, the quotient oxLDL/LDL was lowered by 6.8 +/- 2.1% (p < 0.0166), the MDA concentration remained unchanged and the lipoprotein(a) concentration decreased by 15.8 +/- 5.6% (p < 0.0469) in the patients' blood. The concentration of the nanoplaque promoting particles VLDL and total triglycerides was diminished by 34.1 +/- 11.6% (p < 0.0469) and 26.7 +/- 10.8% (p < 0.0156), respectively. Furthermore, the ratio of the strongly atherogenic small dense to the total LDL cholesterol (LDL5+LDL6)/LDLtot decreased by 9.9 +/- 3.0% (p < 0.0174). CONCLUSIONS: A combinatorial regression analysis revealed a basis for a mechanistic explanation of nanoplaque reduction under n-3 fatty acid treatment. This effect was possibly due to the beneficial changes in lipid concentrations and an attenuation of the risk factors oxLDL/LDL and (LDL5+LDL6)/LDLtot. |
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Authors:
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Cordelia Koppe; Miguel Rodr?guez; Karl Winkler; Jens Pietzsch; Konrad Neumann; Nicola E Hiemann; Roland Hetzer; Martin Malmsten; G?nter Siegel |
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Publication Detail:
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Type: Journal Article Date: 2009-08-13 |
Journal Detail:
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Title: Forschende Komplement?rmedizin (2006) Volume: 16 ISSN: 1661-4127 ISO Abbreviation: Forsch Komplementmed Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-04 Completed Date: 2010-02-01 Revised Date: 2010-05-13 |
Medline Journal Info:
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Nlm Unique ID: 101269884 Medline TA: Forsch Komplementmed Country: Switzerland |
Other Details:
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Languages: eng Pagination: 237-45 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Institute of Physiology, Charit?, Campus Benjamin Franklin, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arteriosclerosis / pathology*, prevention & control* Calcium / blood Endothelium, Vascular / pathology Fatty Acids, Omega-3 / administration & dosage* Female Heart Valve Diseases / pathology, surgery* Heart Valves / pathology Humans Lipids / blood Lipoproteins / blood Male Middle Aged Models, Cardiovascular Nanotechnology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Lipids; 0/Lipoproteins; 7440-70-2/Calcium |
| Comments/Corrections | |
Erratum In:
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Forsch Komplementmed. 2009 Oct;16(5):312 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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