Document Detail


Reduction of aneurysm pressure and wall stress after endovascular repair of abdominal aortic aneurysm in a canine model.
MedLine Citation:
PMID:  8733869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A canine model was designed to evaluate the changes in abdominal aortic aneurysm (AAA) pressure and wall stress after endovascular repair. Eight canines underwent laparotomy and creation of an AAA. The aneurysm was then excluded with a transluminally placed endovascular graft (TPEG) inserted through the right femoral artery and deployed across the AAA to exclude the infrarenal aortic branches from aortic perfusion. Blood pressure and flow data were recorded for 6 hours. The AAA blood pressure decreased from 135 +/- 9.3 mm Hg before exclusion to 45 +/- 17.6 mm Hg at 10 minutes after exclusion (p < 0.001). At 6 hours, AAA blood pressure had declined further to 26 +/- 12.5 mm Hg. Blood flow in the excluded iliac artery decreased from a baseline of 242 +/- 58 ml/min to 41 +/- 29 ml/min 10 minutes after TPEG placement (p < 0.001). At 6 hours, flow was reduced to 12 +/- 3.5 ml/min (p < 0.05 compared with that at 10 minutes). Aortic wall stress was significantly reduced by TPEG placement but was only slightly lower than baseline aortic wall stress before AAA creation. The lumbar arteries were patent with retrograde flow in all cases and were found to be the major contributors to postexclusion aneurysm pressure. Endovascular AAA exclusion results in an immediate decrease in blood pressure and wall stress within the excluded aneurysm, but the aneurysm remains perfused by retrograde flow through the lumbar arteries, which resulted in near-baseline levels of aneurysm wall stress in this canine model. Embolization of patient lumbar vessels at prosthesis placement may further reduce the risk of late rupture.
Authors:
W A Marston; E Criado; C A Baird; B A Keagy
Related Documents :
23386369 - Cerebral hemodynamic changes in obstructive sleep apnea syndrome after continuous posit...
2677089 - Left subclavian flap aortoplasty for coarctation of the aorta: effects on forearm vascu...
2143839 - Percutaneous transluminal angioplasty for atheromatous renal artery stenosis--blood pre...
9678279 - Coronary wallstents show significant late, postprocedural expansion despite implantatio...
16172859 - Necrophysiological determination of blood pressure in fishes.
971339 - Water flux through porcine aortic tissue due to a hydrostatic pressure gradient.
15699449 - Adducin polymorphism: detection and impact on hypertension and related disorders.
12771609 - Usefulness of left ventricular stroke volume variation to assess fluid responsiveness i...
22298419 - Lung aeration changes after lung recruitment in children with acute lung injury: a feas...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  10     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  166-73     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of North Carolina at Chapel Hill School of Medicine 27599-7210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / physiopathology
Aortic Aneurysm, Abdominal / physiopathology,  surgery*
Aortic Rupture / prevention & control
Arteries / physiopathology
Blood Pressure*
Blood Vessel Prosthesis*
Dogs
Embolization, Therapeutic
Graft Occlusion, Vascular / etiology
Hemorheology*
Iliac Artery / physiopathology
Lumbar Vertebrae / blood supply
Male
Regional Blood Flow
Stress, Mechanical
Thrombosis / etiology
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Totally laparoscopic aortobifemoral bypass grafting in an experimental model: description of techniq...
Next Document:  Resistance to activated protein C: a common inherited cause of venous thrombosis.