| Reduction of Nup107 attenuates the growth factor signaling in the senescent cells. | |
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MedLine Citation:
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PMID: 20833136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypo-responsiveness to growth factors is a fundamental feature of cellular senescence. In this study, we found markedly decreased level of Nup107, a key scaffold protein in nuclear pore complex assembly, in senescent human diploid fibroblasts as well as in organs of aged mice. Depletion of Nup107 by specific siRNA in young human diploid fibroblasts prevented the effective nuclear translocation of phosphorylated extracellular signal-regulated kinase (ERK) following epidermal growth factor (EGF) stimulation, and decreased the expression of c-Fos in consequence. The disturbances in ERK signaling in Nup107 depleted cells closely mirror the similar changes in senescent cells. Knockdown of Nup107 in anaplastic oligodendroglioma cells caused cell death, rather than growth retardation, indicating a greater sensitivity to Nup107 depletion in cancer cells than in normal cells. These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules. |
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Authors:
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Sung Young Kim; Hyun Tae Kang; Hae Ri Choi; Sang Chul Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 401 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Active Transport, Cell Nucleus
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drug effects Animals Cell Aging* Cell Line, Tumor Cell Proliferation Child Epidermal Growth Factor / metabolism*, pharmacology Humans Male Mice Mice, Inbred C57BL Nuclear Pore Complex Proteins / antagonists & inhibitors, genetics, metabolism* Phosphorylation Proto-Oncogene Proteins c-fos / metabolism Signal Transduction eIF-2 Kinase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/NUP107 protein, human; 0/Nuclear Pore Complex Proteins; 0/Proto-Oncogene Proteins c-fos; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.-/PERK kinase; EC 2.7.11.1/eIF-2 Kinase |
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