| Reduction of Langerhans cells in human epidermis during PUVA therapy: a morphometric study. | |
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MedLine Citation:
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PMID: 7086168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skin biopsies were obtained before and after PUVA therapy from the normal skin of 5 psoriatic patients. By electron microscopic morphometric techniques the pretreatment volume density of Langerhans cells within the epidermis was estimated to be approximately 1%. This density was reduced in all 5 patients after therapy. The volume density of Langerhans cell granules per Langerhans cell cytoplasm was on an average 0.8% and this density was reduced in 4 of the patients after therapy, while in one patient there was an increase. There was a reduced volume density of Langerhans cell granules per unit volume of epidermis in all 5 patients after therapy. The mean length of the Langerhans cell disc was 260 +/- 120, nm the mean thickness 40 nm and the mean diameter of the Langerhans cell vesicle 120 +/- 30 nm. None of these parameters changed after PUVA therapy. The reduced volume density of Langerhans cells is discussed in the context of possible implications for immune reactions in the skin. |
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Authors:
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K Ree |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 78 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-08-07 Completed Date: 1982-08-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 488-92 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Count Cytoplasmic Granules / ultrastructure Humans Langerhans Cells / pathology, ultrastructure* Male PUVA Therapy* Photochemotherapy* Psoriasis / drug therapy, pathology* |
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