Document Detail


Reduction of CD47 on monocytes correlates with MODS in burn patients.
MedLine Citation:
PMID:  20594756     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Alternation of surface markers on monocytes is associated with the development of inflammation. The goals of the present study were to detect CD47 expression on monocytes by flow cytometry and explore its relationship with disease severity and MODS in burned patients. The results show CD47 expression on monocytes from all burned patients (n = 21) was lower than that from the healthy population (n = 21) for 24 days after burn. There was a significant difference in CD47 expression on monocytes between the patients with differing burn severity in the first 7 days after injury (P < 0.05). Considering the relationship between CD47 expression and MODS, we found the CD47 expression on monocytes from patients with MODS was lower (P < 0.05) in the first 3 days after injury than that from patients without MODS. In conclusion, diminished CD47 expression on monocytes is associated with burn severity and the occurrence of MODS in burn patients.
Authors:
Guang-Qing Wang; Yi Zhang; Hang-Qing Wu; Wei-Wei Zhang; Jun Zhang; Guang-Yi Wang; Shi-Chu Xiao; Zhao-Fan Xia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  37     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd and ISBI. All rights reserved.
Affiliation:
Department of Experimental Medicine, Changhai Hospital, Second Military Medical University, Shanghai, PR China. guangqing_wang@yahoo.com
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