Document Detail


Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats.
MedLine Citation:
PMID:  21071835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 µg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.
Authors:
Kazuyuki Hiwatashi; Hitoshi Shirakawa; Kazuyuki Hori; Yumiko Yoshiki; Nao Suzuki; Mika Hokari; Michio Komai; Saori Takahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  74     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-23     Revised Date:  2011-08-11    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2310-2     Citation Subset:  IM    
Affiliation:
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Humans
Inhibitory Concentration 50
Rats
Rats, Inbred SHR
Renin / antagonists & inhibitors*
Saponins / administration & dosage,  pharmacology*
Soybeans / chemistry*
Chemical
Reg. No./Substance:
0/Saponins; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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