| Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 21071835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 µg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure. |
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Authors:
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Kazuyuki Hiwatashi; Hitoshi Shirakawa; Kazuyuki Hori; Yumiko Yoshiki; Nao Suzuki; Mika Hokari; Michio Komai; Saori Takahashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 74 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2011-03-23 Revised Date: 2011-08-11 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 2310-2 Citation Subset: IM |
Affiliation:
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Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Humans Inhibitory Concentration 50 Rats Rats, Inbred SHR Renin / antagonists & inhibitors* Saponins / administration & dosage, pharmacology* Soybeans / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Saponins; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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