| Reducing safety-related drug attrition: the use of in vitro pharmacological profiling. | |
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MedLine Citation:
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PMID: 23197038 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In vitro pharmacological profiling is increasingly being used earlier in the drug discovery process to identify undesirable off-target activity profiles that could hinder or halt the development of candidate drugs or even lead to market withdrawal if discovered after a drug is approved. Here, for the first time, the rationale, strategies and methodologies for in vitro pharmacological profiling at four major pharmaceutical companies (AstraZeneca, GlaxoSmithKline, Novartis and Pfizer) are presented and illustrated with examples of their impact on the drug discovery process. We hope that this will enable other companies and academic institutions to benefit from this knowledge and consider joining us in our collaborative knowledge sharing. |
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Authors:
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Joanne Bowes; Andrew J Brown; Jacques Hamon; Wolfgang Jarolimek; Arun Sridhar; Gareth Waldron; Steven Whitebread |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature reviews. Drug discovery Volume: 11 ISSN: 1474-1784 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: England |
Other Details:
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Languages: eng Pagination: 909-22 Citation Subset: IM |
Affiliation:
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1] AstraZeneca R&D, Alderley Park, Cheshire SK10 4TG, UK. [2]. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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