| Reducing the risk of ventricular fibrillation by adding sodium to ionic and non-ionic contrast media with low iodine concentration. Coronary perfusion of the isolated rabbit heart with meglumine diatrizoate or iopentol at 140 mg I/ml and 0-154 mmol Na+/l. | |
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MedLine Citation:
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PMID: 2647114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the fibrillatory propensity of low concentrations of contrast media (140 mg I/ml) the ionic, ratio 1.5, contrast medium meglumine diatrizoate, the non-ionic, ratio 3, medium iopentol and equimolar glucose (0.37 mol/l) were perfused into 35 isolated rabbit hearts. The three substances were compared at three levels of sodium concentration (0.77 and 154 mmol Na+/l). Meglumine diatrizoate without sodium caused the highest frequency of ventricular fibrillation (91%). Iopentol without sodium caused a significantly lower frequency of ventricular fibrillation (17%). Glucose without sodium caused no fibrillation. The addition of 77 or 154 mmol Na+/l significantly decreased the frequency of ventricular fibrillation of both meglumine diatrizoate (3% and 6%) and iopentol (0%). Meglumine diatrizoate with sodium added caused a lower frequency of ventricular fibrillation than iopentol without sodium. At equal sodium concentrations (0.77 and 154 mmol Na+/l) glucose caused smaller reduction in contractile force and heart rate than iopentol, and iopentol caused smaller reduction in contractile force and heart rate than diatrizoate. It is concluded that addition of sodium to ionic or non-ionic contrast media without sodium decreases the risk of ventricular fibrillation. |
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Authors:
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L Bååth; T Almén |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 30 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1989 Mar-Apr |
Date Detail:
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Created Date: 1989-04-26 Completed Date: 1989-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Experimental Research, Malmö, Allmänna Sjukhus, University of Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiocardiography* Animals Contrast Media / administration & dosage*, adverse effects Diatrizoate Meglumine / administration & dosage Female Glucose / administration & dosage Heart Arrest / prevention & control Heart Rate / drug effects Iodine / administration & dosage* Male Myocardial Contraction / drug effects Osmolar Concentration Rabbits Risk Factors Sodium / administration & dosage* Triiodobenzoic Acids / administration & dosage Ventricular Fibrillation / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Triiodobenzoic Acids; 131-49-7/Diatrizoate Meglumine; 50-99-7/Glucose; 7440-23-5/Sodium; 7553-56-2/Iodine; 89797-00-2/iopentol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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