| Reducing psychosocial stress: a novel mechanism of improving survival from exercise training. | |
| | |
MedLine Citation:
|
PMID: 19682669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Exercise training reduces mortality in patients with coronary artery disease. Behavioral characteristics, including depression, hostility, and overall psychosocial stress, have been shown to be independent risk factors for recurrent myocardial infarction and death in these patients. Exercise training can reduce these high-risk behaviors, but it remains uncertain as to what extent the health benefits of exercise training can be attributed to improving these behaviors. METHODS: We evaluated the impact of exercise training during cardiac rehabilitation on mortality in 53 patients with coronary artery disease with high levels of psychosocial stress and in 469 patients with coronary artery disease with low levels of psychosocial stress and compared them with 27 control patients with high psychosocial stress who did not undergo formal cardiac rehabilitation and exercise training. RESULTS: Mortality was approximately 4-fold greater in patients with high psychosocial stress than in those with low psychosocial stress (22% vs 5%; P = .003). Exercise training decreased the prevalence of psychosocial stress from 10% to 4% (P<.0001) and similarly improved peak oxygen uptake in patients with high and low psychosocial stress. Mortality in patients who improved exercise capacity by>or=10% (high exercise change) was 60% lower than in patients who had<10% improvement in exercise capacity (low exercise change) (P=.009). Mortality was lower in patients with high psychosocial stress with high exercise change compared with patients with high psychosocial stress with low exercise change (0% vs 19%; P=.009). In contrast, there was no significant improvement in mortality in patients with high versus low exercise change with low psychosocial stress (4% vs 8%; P=.14). CONCLUSION: Psychosocial stress is an independent risk factor for mortality in patients with coronary artery disease, and exercise training can effectively reduce its prevalence. Exercise training reduces mortality in patients with coronary artery disease, and this effect seems to be mediated in part because of the salutary effects of exercise on psychosocial stress. |
| | |
Authors:
|
Richard V Milani; Carl J Lavie |
Related Documents
:
|
16917019 - Possible inhibitory role of prolactin-releasing peptide for acth release associated wit... 1921679 - Exercise training and response to stress: insights from an animal model. 1985309 - The link between stress and illness. do our coping methods influence our health? 20658249 - Separate and combined effects of heat stress and exercise on circulatory markers of oxi... 17258319 - Biomarkers and bioindicators of the health condition of ameca splendens and goodea atri... 18954159 - Chronic psychosocial factors and acute physiological responses to laboratory-induced st... 11005959 - Study of charmless hadronic b meson decays to pseudoscalar-vector final states. 20654739 - Influence of body position on muscle deoxy[hb+mb] during ramp cycle exercise. 3503259 - Children's perception of parental exercise: influence of sex and age. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2009-08-13 |
Journal Detail:
|
Title: The American journal of medicine Volume: 122 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-29 Completed Date: 2009-10-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
|
Languages: eng Pagination: 931-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA. rmilani@ochsner.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Transluminal, Percutaneous Coronary / methods Case-Control Studies Coronary Artery Bypass / methods Coronary Disease / mortality*, psychology, rehabilitation*, therapy Exercise / physiology* Exercise Therapy / methods Female Humans Male Middle Aged Physical Fitness / physiology Probability Prognosis Psychology Quality of Life* Reference Values Risk Assessment Severity of Illness Index Stress, Psychological / mortality, rehabilitation Survival Analysis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women.
Next Document: Incidence of thrombocytopenia in hospitalized patients with venous thromboembolism.