Document Detail

Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats.
MedLine Citation:
PMID:  20338076     Owner:  NLM     Status:  MEDLINE    
Extracts from or derivatives of Phaseolus vulgaris beans reduce body weight and food intake, including highly palatable foods and fluids, in multiple rodent models of overeating and obesity. The present study was designed to assess whether a standardised P. vulgaris dry extract was effective in reducing also the operant self-administration of a chocolate-flavoured beverage. To this end, rats were initially trained to lever-press for a chocolate-flavoured beverage under a fixed ratio 10 schedule of reinforcement in daily 60 min sessions. Once lever-responding reached stable levels, the effect of a P. vulgaris dry extract on the number of lever-responses for the chocolate-flavoured beverage was determined. Pretreatment with 50, 200 and 500 mg (intragastric) P. vulgaris dry extract per kg produced an approximate 15, 35 and 40 % reduction, respectively, in lever-responding for the chocolate-flavoured beverage. These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats.
Paola Maccioni; Giancarlo Colombo; Antonella Riva; Paolo Morazzoni; Ezio Bombardelli; Gian Luigi Gessa; Mauro A M Carai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-26
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-09-22     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  624-8     Citation Subset:  IM    
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MeSH Terms
Appetite Depressants / pharmacology*
Behavior, Animal / drug effects*
Conditioning, Operant / drug effects*
Dose-Response Relationship, Drug
Plant Extracts / pharmacology*
Rats, Wistar
Reinforcement Schedule
Self Administration
Reg. No./Substance:
0/Appetite Depressants; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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