| Reducing blood glucose variability by use of abdominal insulin injection sites. | |
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MedLine Citation:
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PMID: 2076628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Virtually all patients with type I diabetes are familiar with inexplicable fluctuations in blood glucose concentration that expose them to both hypoglycemia and hyperglycemia. It is commonly assumed that such fluctuations are due, in large part, to variations in food intake, physical activities, and emotional state. However, substantial day-to-day variation in blood glucose concentration is observed when diet, exercise, emotional state, insulin dosage, and timing of insulin administration are held constant. This suggests that variation in the rate of absorption of insulin from the subcutaneous injection sites may be an important factor causing those fluctuations. Variations in insulin absorption are increased if the anatomic regions used for injections are rotated. A recent study completed at the University of Minnesota Hospital and Clinic indicates that it is inadvisable for type I diabetic subjects to rotate insulin injection regions; rather, insulin injections should be confined to a single anatomic region (usually the abdomen) as this will decrease day-to-day variability in blood glucose concentration. Such a decrease should allow greater precision in adjusting insulin doses, thereby helping achieve good control. |
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Authors:
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C Zehrer; R Hansen; J Bantle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Diabetes educator Volume: 16 ISSN: 0145-7217 ISO Abbreviation: Diabetes Educ Publication Date: 1990 Nov-Dec |
Date Detail:
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Created Date: 1991-04-25 Completed Date: 1991-04-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7701401 Medline TA: Diabetes Educ Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 474-7 Citation Subset: N |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Adult Blood Glucose / analysis* Chronic Disease Diabetes Mellitus, Type 1 / blood, drug therapy Feeding Behavior / physiology Female Humans Injections, Subcutaneous / methods Insulin / administration & dosage* Male Middle Aged Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MO1-RR-00400/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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