| Reducing Rates of Severe Hypoglycemia in a Population-Based Cohort of Children and Adolescents With Type 1 Diabetes Over the Decade 2000-2009. | |
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MedLine Citation:
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PMID: 21926291 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVETo examine rates of severe hypoglycemia (SH) in a large population-based cohort of children with type 1 diabetes and relationships to HbA(1c).RESEARCH DESIGN AND METHODSData from 1,683 children (mean [SD] age at diagnosis 10.5 ± 4.2; range 1-18 years) from 2000 to 2009 were analyzed from the Western Australian Childhood Diabetes Database. Rates of SH were related to HbA(1c) using negative binomial regression.RESULTSA total of 7,378 patient-years of data and 780 SH events were recorded. The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006. HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%.CONCLUSIONSIn a sample of youth with type 1 diabetes, there has been a decrease in rates of SH and a weaker relationship with glycemic control than previously observed. |
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Authors:
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Susan M O'Connell; Matthew N Cooper; Max K Bulsara; Elizabeth A Davis; Timothy W Jones |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-16 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology and Diabetes, Princess Margaret Hospital for Sick Children, Perth, Western Australia, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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