Document Detail

Reducing hippocampal cell proliferation in the adult rat does not prevent the acquisition of cocaine-induced conditioned place preference.
MedLine Citation:
PMID:  20600607     Owner:  NLM     Status:  MEDLINE    
Neurogenesis is important for developing certain forms of memory. Recently, hippocampal cell proliferation has been implicated in the development of drug addiction, an extreme form of emotional/motivational pathological memory. Aiming to explore the role of hippocampal neural cell proliferation in cocaine-induced conditioned place preference (CPP), we treated rats with whole brain X-irradiation, which substantially decreases the number of progenitor cells in the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus. Surprisingly, there was no difference in the expression of cocaine-induced CPP. These results suggest that the existing neural network, rather than potential new neural circuits mediated by adult neurogenesis, is sufficient for the acquisition of cocaine-induced CPP.
Travis E Brown; Brian R Lee; Vitaly Ryu; Thiebaut Herzog; Krzysztof Czaja; Yan Dong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-23
Journal Detail:
Title:  Neuroscience letters     Volume:  481     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-08     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Adult Stem Cells / drug effects,  radiation effects
Apoptosis / drug effects,  radiation effects
Bromodeoxyuridine / metabolism
Cell Count / methods
Cell Proliferation / drug effects*,  radiation effects
Cocaine / pharmacology*
Conditioning, Operant / drug effects*,  physiology,  radiation effects
Dopamine Uptake Inhibitors / pharmacology*
Hippocampus / cytology*
Neurons / drug effects*,  radiation effects
Rats, Sprague-Dawley
Time Factors
X-Rays / adverse effects
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; G34N38R2N1/Bromodeoxyuridine; I5Y540LHVR/Cocaine

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