| Reduced whole blood serotonin in major depression. | |
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MedLine Citation:
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PMID: 9262942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whole blood serotonin (WBS) was measured in 17 patients with DSM-III-R major depression and compared to a healthy control group of 57. Values were significantly lower in the depressed group, but there was no correlation with the degree of depression. Four patients with a history of suicide attempts had even lower levels, but this was not statistically significant. Across all subjects, there was an effect of season of sampling, with values in spring significantly higher than those in autumn. Since blood serotonin is primarily produced peripherally, these results suggest that some aspect of peripheral serotonin metabolism is abnormal in major depression. |
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Authors:
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A J Cleare |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Depression and anxiety Volume: 5 ISSN: 1091-4269 ISO Abbreviation: Depress Anxiety Publication Date: 1997 |
Date Detail:
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Created Date: 1997-10-21 Completed Date: 1997-10-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9708816 Medline TA: Depress Anxiety Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 108-11 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Biological Markers / blood Case-Control Studies Cross-Sectional Studies Depressive Disorder / blood* Female Humans Male Periodicity Seasons Serotonin / blood*, secretion Severity of Illness Index Suicide, Attempted |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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