Document Detail

Reduced whole blood serotonin in major depression.
MedLine Citation:
PMID:  9262942     Owner:  NLM     Status:  MEDLINE    
Whole blood serotonin (WBS) was measured in 17 patients with DSM-III-R major depression and compared to a healthy control group of 57. Values were significantly lower in the depressed group, but there was no correlation with the degree of depression. Four patients with a history of suicide attempts had even lower levels, but this was not statistically significant. Across all subjects, there was an effect of season of sampling, with values in spring significantly higher than those in autumn. Since blood serotonin is primarily produced peripherally, these results suggest that some aspect of peripheral serotonin metabolism is abnormal in major depression.
A J Cleare
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Depression and anxiety     Volume:  5     ISSN:  1091-4269     ISO Abbreviation:  Depress Anxiety     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-21     Completed Date:  1997-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9708816     Medline TA:  Depress Anxiety     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-11     Citation Subset:  IM    
Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Case-Control Studies
Cross-Sectional Studies
Depressive Disorder / blood*
Serotonin / blood*,  secretion
Severity of Illness Index
Suicide, Attempted
Reg. No./Substance:
0/Biological Markers; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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