| Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases. | |
| | |
MedLine Citation:
|
PMID: 18175284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thrombotic thrombocytopenic purpura (TTP) is a severe multisystem thrombotic microangiopathy (TMA). Significant advances have been made in understanding the pathogenesis of TTP since the discovery of ADAMTS-13 ( A Disintegrin And Metalloproteinase with Thrombo Spondin-1-like domains), the enzyme that regulates the size of von Willebrand factor (VWF) multimers. The inherited forms of TTP are mainly caused by a severe ADAMTS-13 deficiency, yet many aspects of the complex biological relationships between VWF-cleaving metalloproteinase and acquired TMA are still unclear. This latter issue will be critically addressed in this review article. In addition, the published literature evaluating plasma ADAMTS-13 levels in other pathologic conditions different from TMA will also be discussed. |
| | |
Authors:
|
Massimo Franchini; Martina Montagnana; Giovanni Targher; Giuseppe Lippi |
Related Documents
:
|
15188964 - Iron deficiency and iron deficiency anaemia during infancy and childhood. 7533564 - Effect of iron-deficiency anaemia on cognitive skills in infancy and childhood. 989894 - Iron sufficiency in breast-fed infants and the availability of iron from human milk. 641274 - Influence of a nutrition education program (efnep) on infant nutrition in east harlem. 18310194 - Effect of oxygen supplementation on length of stay for infants hospitalized with acute ... 15568214 - Maternal smoking, intrauterine growth restriction, and placental apoptosis. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Seminars in thrombosis and hemostasis Volume: 33 ISSN: 0094-6176 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2008-01-04 Completed Date: 2008-02-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: United States |
Other Details:
|
Languages: eng Pagination: 787-97 Citation Subset: IM |
Affiliation:
|
Servizio di Immunoematologia e Trasfusione - Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. massimo.franchini@univr.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ADAM Proteins
/
blood*,
deficiency Autoimmune Diseases / enzymology Bone Marrow Transplantation Female Humans Infection / blood Neoplasms / enzymology Pregnancy Purpura, Thrombotic Thrombocytopenic / enzymology* Thrombosis / enzymology* von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/von Willebrand Factor; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet-type von Willebrand disease and type 2B von Willebrand disease: a story of nonidentical twi...
Next Document: Hemostatic dysfunction associated with endocrine disorders as a major risk factor and cause of human...