Document Detail

Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy. The Cardiovascular Health Study.
MedLine Citation:
PMID:  7813294     Owner:  NLM     Status:  MEDLINE    
The Cardiovascular Health Study provided the opportunity to determine the association of subclinical and clinical cardiovascular disease with pulmonary function in a population sample of elderly adults. Included were 2,955 women and 2,246 men over age 64 years who were recruited for this observational study from four communities and completed extensive examinations that included spirometry, echocardiograms, and blood pressure. Current smokers, past smokers with >20 pack-years of smoking, and persons with a history of asthma, chronic bronchitis, or emphysema were excluded from this analysis, leaving 2,784 (55%) of the cohort. Systolic hypertension or coronary artery disease was associated with 40- to 100-mL decrements in FEV1, and 50- to 150-mL decrements in FVC, while a history of congestive heart failure was associated with 200 to 300 mL lower FEV1 and FVC values (p < 0.0001), after correcting for age, height, and waist size. Higher left ventricular (LV) mass was also significantly associated with a decrease in FEV1 and FVC in multivariate models. This relationship was strongest with the end-diastolic LV posterior wall thickness component of LV mass. In summary, FEV1 and FVC are reduced in elderly persons with hypertension, ischemic heart disease, higher disease, higher LV mass, and congestive heart failure, though the magnitude of these associations is relatively small unless heart failure supervenes. Substantial decrements in percent predicted FEV1 and FVC should not be attributed to the presence of uncomplicated ischemic heart disease or hypertension alone.
P L Enright; R A Kronmal; V E Smith; J M Gardin; M B Schenker; T A Manolio
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  107     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-07     Completed Date:  1995-02-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  AIM; IM    
CHS Coordinating Center, Seattle, WA 98101.
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MeSH Terms
Age Factors
Aged, 80 and over
Coronary Disease / physiopathology*
Forced Expiratory Volume
Hypertension / physiopathology*
Hypertrophy, Left Ventricular / physiopathology*
Middle Aged
Ventricular Function, Left
Vital Capacity*
Grant Support
N01-85079//PHS HHS; N01-85080//PHS HHS; N01-85081//PHS HHS
Comment In:
Chest. 1995 Jan;107(1):6-7   [PMID:  7813313 ]

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