Document Detail

Reduced visual resolution acuity and cerebral white matter damage in very-low-birthweight infants.
MedLine Citation:
PMID:  11132254     Owner:  NLM     Status:  MEDLINE    
Neonatal cerebral white matter echolucencies predict visual resolution acuity deficits in very-low-birthweight (VLBW) infants. We examined maternal sociodemographic, lifestyle, intrapartum, infant birth/perinatal, and ocular motor/refractive characteristics to determine whether they accounted for this association in infants who were tested once between postnatal age 25 and 56 weeks (corrected for gestational age at birth). Cranial ultrasound scans were read by consensus to identify echolucency in a population of VLBW infants with no known ocular abnormalities. Visual resolution acuity was measured with the Acuity Card Procedure (ACP) in 14 infants with echolucency and compared with that of 81 VLBW infants born in the same hospitals with normal ultrasound scans. In time-oriented logistic regression models, echolucency remained a consistent predictor of abnormal visual resolution acuity after adjustment for covariates in three developmental periods (pre-, peri-, and postnatal). Odds ratios ranged from 19.3 (95% confidence interval, 4.5 to 82.2; p=0.001) to 10.4 (95% confidence interval, 1.3 to 81.9; p=0.03). Reduced visual resolution acuity in VLBW infants appears to be due to cerebral white matter damage.
J P SanGiovanni; E N Allred; D L Mayer; J E Stewart; M G Herrera; A Leviton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  42     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-22     Completed Date:  2001-01-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-15     Citation Subset:  IM    
National Eye Institute, Division of Epidemiology and Clinical Research, National Institutes of Health Building, Bethesda, MD 20892-2510, USA.
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MeSH Terms
Cerebral Cortex / pathology*,  ultrasonography
Infant, Newborn
Infant, Very Low Birth Weight*
Odds Ratio
Risk Factors
Vision Disorders / physiopathology*
Visual Acuity*
Grant Support

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