Document Detail


Reduced venous admixture in hemorrhagic hypovolemia: maintenance of arterial oxygenation by selective pulmonary vascular collapse.
MedLine Citation:
PMID:  2298014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In nine anesthetized and ventilated swine, a microcomputer calculated cardiac output, venous admixture (Qsp/Qt) and physiologic deadspace (VD/VT) every 20 sec, utilizing dual oximetry and a gas exchange analyzer. After lung injury with ethchlorvynol (ECV), animals were bled 40% blood volume over 40 min. Mean cardiac output decreased 7.0 to 2.2 L/min (p less than .05) accompanied by a decrease in mean Qsp/Qt from 0.28 to 0.14 (p less than .05) and an increase in mean VD/VT from 0.39 to 0.54 (p less than .05). Arterial Hgb saturation (Sao2) increased from 88 +/- 7% to 90 +/- 6%. On regression of all data points for each variable, Qsp/Qt had a positive correlation with cardiac output (r = .90), mean arterial pressure (MAP, r = .87), mean pulmonary artery pressure (MPAP, r = .86), and mixed venous Hgb saturation (Svo2, r = .89, p less than .001). VD/VT had an inverse correlation with cardiac output (r = -.90), MAP (r = -.82), Qsp/Qt (r = -.83), MPAP (r = -.77), and Svo2 (r = -.92, p less than .001). The decreasing Qsp/Qt and increasing VD/VT, with decreasing pulmonary perfusion pressures, were attributed to selective loss of perfusion to alveoli with low ventilation/perfusion ratios.
Authors:
G D Kamal; T Symreng; D J Tatman; P J Jebson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  18     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-12     Completed Date:  1990-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ethchlorvynol / poisoning
Lung Diseases / chemically induced,  physiopathology*
Microcomputers
Monitoring, Physiologic
Oximetry
Shock / physiopathology*
Swine
Chemical
Reg. No./Substance:
113-18-8/Ethchlorvynol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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