Document Detail

Reduced urinary excretion of prostaglandin E in essential hypertension.
MedLine Citation:
PMID:  6348805     Owner:  NLM     Status:  MEDLINE    
To ascertain whether renal prostaglandin (PG) E synthesis is decreased in patients with essential hypertension (EH), urinary PGE excretion (UPGEV) was measured in 47 normal females and 62 female patients with EH. In order to avoid contaminations of urine by seminal fluids, only female subjects were studied. UPGEV was also measured in female patients with renovascular hypertension (RVH) as well as primary aldosteronism (PA) or idiopathic hyperaldosteronism (IHA). As a whole, UPGEV was lower in patients with EH (226.9 +/- 13.7 ng/day) than that in normal females (317.3 +/- 22.1 ng/day, p less than 0.001). Younger patients (15 to 39 years) had significantly lower UPGEV than normal females of corresponding ages. However, there was no significant difference in UPGEV between older patients (over 40 years) with EH and normal females of the same age range. There were no significant differences in UPGEV among patients with low renin EH, normal renin EH, RVH, PA and IHA. We reconfirmed the decrease in UPGEV in patients with EH as compared with normal controls by studying female subjects. Further, it is suggested that renal PGE synthesis is not influenced by the renin-angiotensin system in these hypertensive states.
K Sato; K Abe; M Seino; M Yasujima; S Chiba; M Sato; T Haruyama; M Hiwatari; T Goto; J Tajima; M Tanno; K Yoshinaga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  11     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
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MeSH Terms
Age Factors
Hyperaldosteronism / urine
Hypertension / metabolism,  urine*
Hypertension, Renovascular / urine
Kidney / metabolism
Middle Aged
Prostaglandins E / biosynthesis,  urine*
Renin / blood
Reg. No./Substance:
0/Prostaglandins E; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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