Document Detail


Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis.
MedLine Citation:
PMID:  15047551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC(50)) of 0.12 microg/ml and a MIC(90) of 0.25 microg/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC(50) of 0.12 microg/ml and a MIC(90) of 8 microg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.
Authors:
Molly B Schmid; Nachum Kaplan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  48     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-05-24     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1397-9     Citation Subset:  IM    
Affiliation:
Affinium Pharmaceuticals, Inc., Toronto, Ontario M5J 1V6, Canada.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / pharmacology*
Humans
Methicillin Resistance*
Microbial Sensitivity Tests
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects*
Triclosan / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 3380-34-5/Triclosan
Comments/Corrections

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