| Reduced transverse relaxation rate (RR2) for improved sensitivity in monitoring myocardial iron in thalassemia. | |
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MedLine Citation:
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PMID: 21591022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the reduced transverse relaxation rate (RR2), a new relaxation index which has been shown recently to be primarily sensitive to intracellular ferritin iron, as a means of detecting short-term changes in myocardial storage iron produced by iron-chelating therapy in transfusion-dependent thalassemia patients. MATERIALS AND METHODS: A single-breathhold multi-echo fast spin-echo sequence was implemented at 3 Tesla (T) to estimate RR2 by acquiring signal decays with interecho times of 5, 9 and 13 ms. Transfusion-dependent thalassemia patients (N = 8) were examined immediately before suspending iron-chelating therapy for 1 week (Day 0), after a 1-week suspension of chelation (Day 7), and after a 1-week resumption of chelation (Day 14). RESULTS: The mean percent changes in RR2, R2, and R2* off chelation (between Day 0 and 7) were 11.9 ± 8.9%, 5.4 ± 7.7% and -4.4 ± 25.0%; and, after resuming chelation (between Day 7 and 14), -10.6 ± 13.9%, -8.9 ± 8.0% and -8.5 ± 24.3%, respectively. Significant differences in R2 and RR2 were observed between Day 0 and 7, and between Day 7 and 14, with the greatest proportional changes in RR2. No significant differences in R2* were found. CONCLUSION: These initial results demonstrate that significant differences in RR2 are detectable after a single week of changes in iron-chelating therapy, likely as a result of superior sensitivity to soluble ferritin iron, which is in close equilibrium with the chelatable cytosolic iron pool. RR2 measurement may provide a new means of monitoring the short-term effectiveness of iron-chelating agents in patients with myocardial iron overload. |
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Authors:
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Jerry S Cheung; Wing-Yan Au; Shau-Yin Ha; Daniel Kim; Jens H Jensen; Iris Y Zhou; Matthew M Cheung; Yin Wu; Hua Guo; Pek-Lan Khong; Truman R Brown; Gary M Brittenham; Ed X Wu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-10-03 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1510-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Transfusion Chelating Agents / pharmacology Chelation Therapy / methods Cytosol / metabolism Female Ferritins / chemistry Hemosiderin / chemistry Humans Iron / chemistry Magnetic Resonance Imaging / methods Male Myocardium / pathology* Thalassemia / diagnosis, pathology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK049108-10/DK/NIDDK NIH HHS; R01 DK066251-04/DK/NIDDK NIH HHS; R01 DK069373-03/DK/NIDDK NIH HHS; R01-DK049108/DK/NIDDK NIH HHS; R01-DK066251/DK/NIDDK NIH HHS; R01-DK069373/DK/NIDDK NIH HHS; R37 DK049108-17/DK/NIDDK NIH HHS; R37 DK049108-18/DK/NIDDK NIH HHS; R37-DK049108/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 7439-89-6/Iron; 9007-73-2/Ferritins; 9011-92-1/Hemosiderin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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