Document Detail

Reduced tissue arachidonic acid concentration with chronic ethanol feeding in miniature pigs.
MedLine Citation:
PMID:  1503056     Owner:  NLM     Status:  MEDLINE    
The effect of ethanol feeding on the essential fatty acid content of tissues has been contradictory. To define the effect, we analyzed fatty acid profiles in various tissues from five miniature pigs fed daily 105 kJ basal diet/kg body wt and 146 kJ ethanol/kg body wt, and also five control pigs pair-fed the same amount of basal diet but with corn starch substituted for ethanol. After 12 mo, biopsy samples were taken, and tissue fatty acid profiles were analyzed. In the phospholipid fraction from the ethanol group there was a uniform decrease in arachidonic acid (AA) and an increase in oleic acid in liver, serum, and muscle. AA was consistently decreased in the triglyceride fractions of liver, serum and subcutaneous adipose of the ethanol group. Possible explanations for this general reduction in tissue AA with ethanol feeding include decreased activities of delta 6 and delta 5 desaturases, and a displacement of AA from lipid fractions by other fatty acids.
M T Nakamura; A B Tang; J Villanueva; C H Halsted; S D Phinney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  56     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-74     Citation Subset:  AIM; IM    
Division of Clinical Nutrition and Metabolism, School of Medicine, University of California, Davis 95616.
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MeSH Terms
Adipose Tissue / chemistry*
Arachidonic Acid / analysis*
Ethanol / administration & dosage*
Fatty Acids, Essential / analysis*
Fatty Acids, Nonesterified / analysis
Fatty Acids, Unsaturated / analysis*
Liver / chemistry*
Muscles / chemistry*
Oleic Acid
Oleic Acids / analysis*
Swine, Miniature*
Triglycerides / analysis*
Grant Support
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Oleic Acids; 0/Triglycerides; 112-80-1/Oleic Acid; 506-32-1/Arachidonic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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