| Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics. | |
| | |
MedLine Citation:
|
PMID: 1455095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The act of breathing diminishes the discomfort associated with hypercapnia and breath-holding. To investigate the mechanisms involved in this effect, we studied the effect of tidal volume (VT) on CO2-evoked air hunger in 5 high-level quadriplegic subjects whose ventilatory capacity was negligible, and who lacked sensory information from the chest wall. Subjects were ventilated at constant frequency with a hyperoxic gas mixture, and end-tidal PCO2 was maintained at a constant but elevated level. VT was varied between the subjects' normal VT and a smaller VT. Subjects used a category scale to rate their respiratory discomfort or 'air hunger' at 30-40 sec intervals. In 4 of 5 subjects there was a strong inverse relationship between breath size and air hunger ratings. The quality of the sensation associated with reduced VT was nearly identical to that previously experienced with CO2 alone. We conclude that afferent information from the lungs and upper airways is sufficient to modify the sensation of air hunger. |
| | |
Authors:
|
H L Manning; S A Shea; R M Schwartzstein; R W Lansing; R Brown; R B Banzett |
Related Documents
:
|
9799885 - Mechanical ventilation: simplifying the terminology. 8797405 - Effect of different inspiratory maneuvers on fev1 in patients with cystic fibrosis. 3452445 - Breathing pattern during exercise in myopathic subjects. 12438825 - Mapping for ventricular tachycardia. 701125 - Effects of angiotensin antagonism at rest and during exercise in sodium-deplete man. 6748925 - Effects of high- and low-intensity exercise training on aerobic capacity and blood lipids. |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Respiration physiology Volume: 90 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1992 Oct |
Date Detail:
|
Created Date: 1993-01-07 Completed Date: 1993-01-07 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 19-30 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Beth Israel Hospital, Boston, MA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Carbon Dioxide / metabolism Female Humans Male Middle Aged Quadriplegia / physiopathology*, therapy Respiration, Artificial* Sensation Tidal Volume |
| Grant Support | |
ID/Acronym/Agency:
|
HL19170/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ontogenetic modification of the hypercapnic ventilatory response in the zebra finch.
Next Document: Molecular adaptation of hemoglobin function in mammals.