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Reduced tibial speed of sound in Chinese infants at birth compared with Caucasian peers: the effects of race, gender, and vitamin D on fetal bone development.
MedLine Citation:
PMID:  20135096     Owner:  NLM     Status:  In-Process    
SUMMARY: This study compared bone status between Chinese and Caucasian infants at birth, showing that Chinese neonates have lower tibial speed of sound, which is influenced by gender, gestational age, season of birth, and maternal vitamin D status. The effects of these factors on fetal bone development were discussed.
INTRODUCTION: We compared the differences of speed of sound (SOS) accessed by quantitative ultrasound between Chinese and Caucasian infants at birth and explored the relationship between the concentrations of serum 25-hydroxyvitamin D [25(OH)D] and bone SOS in maternal-infant pairs.
METHODS: SOS for the tibial bone was measured at birth in 267 Chinese infants. We used the Z-scores for the direct comparisons which were available from the instrument based data of gender and age-matched Caucasian peers. The concentrations of serum 25(OH)D and bone SOS in 32 maternal-infant pairs were measured at birth in winters.
RESULTS: the Chinese infants had lower SOS demonstrated by the Z-scores. Significant differences of SOS and Z-scores were found between genders, gestational ages, birth weight, and seasons of birth. The differences of Z-scores negatively decreased with gestational age, suggesting that the bone status of Chinese infants lags behind that of the Caucasian infants during the last trimester of pregnancy in utero. The tibial SOS of infants born in winters was 2.0% higher than those born in summers after adjustment. The infant SOS correlated with maternal serum 25(OH)D (r = 0.399, P = 0.024) and infant serum 25(OH)D (r = 0.394, P = 0.026).
CONCLUSIONS: Chinese neonates have lower SOS which is influenced by gender, gestational age, season of birth, and maternal vitamin D status. It is inferred that, in pace with gestational age, race and gender effects on fetal bone development are modified by materno-fetal vitamin D status.
X P Liao; W L Zhang; C H Yan; X J Zhou; P Wang; J H Sun; X D Yu; M Q Wu
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Publication Detail:
Type:  Journal Article     Date:  2010-02-05
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  21     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  2003-11     Citation Subset:  IM    
Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children's Environmental Health, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
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